{"created":"2023-08-31T02:38:57.149606+00:00","id":2000042,"links":{},"metadata":{"_buckets":{"deposit":"832972e4-5545-4d06-8c84-2dd122bec21d"},"_deposit":{"created_by":16,"id":"2000042","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"2000042"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000042","sets":["334:608:618:1336"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-24","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-24"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: Panic disorder (PD) has many comorbidities such as depression, bipolar disorder (BPD), and agoraphobia (AG). PD is a moderately heritable anxiety disorder whose pathogenesis is not well understood. Recently, a tri-allelic serotonin transporter (5-HTTLPR/rs25531) polymorphism was reported to be more sensitive to personality traits compared to the bi-allelic 5-HTTLPR polymorphism. We hypothesized that the 5-HTTLPR/rs25531 polymorphism may lead to a pathological anxious state depending on the presence or absence of a comorbidity in PD. Methods: In this study, we investigated the relationship between comorbidities in PD and tri-allelic 5-HTTLPR polymorphisms. A total of 515 patients with PD (148 males, 367 females) were genotyped, and the Revised NEO Personality Inventory as well as anxiety-related psychological tests were administered. Depression, BPD, and AG were diagnosed as comorbidities. Results: For the tri-allele 5-HTTLPR genotype, a significant interaction effect was found between openness to experience and comorbid depression. Examination of the interaction between AG and the tri-allelic 5-HTTLPR genotype revealed that L’ allele carriers are associated with higher trait anxiety than the S’S’ genotype group in PD without AG. Conclusion: Some anxiety and personality traits can be characterized by the tri-allelic gene effect of 5-HTTLPR. These results suggest that triallelic 5-HTTLPR genotypes have genetic effects on the presence of comorbidities of PD","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Division of Neuroscience, Department of Psychiatry, Graduate School of Medicine, Brain Science and Animal Model Research Center, Mie University, Tsu, Japan","subitem_description_type":"Other"},{"subitem_description":"11p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙医学第1083号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1159/000512699","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Neuropsychobiology 2021;80:333-341に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tanahashi, Shunsuke","creatorNameLang":"en"},{"creatorName":"タナハシ, シュンスケ","creatorNameLang":"ja-Kana"},{"creatorName":"棚橋, 俊介","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-24"}],"displaytype":"detail","filename":"2022DM0346.pdf","filesize":[{"value":"406KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2022DM0346","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/2000042/files/2022DM0346.pdf"},"version_id":"d19eb881-797e-41ab-b47c-7aa889c2ec85"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"5-HTTLPR","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Agoraphobia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Comorbidity","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Depression","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Panic disorder","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Association of Serotonin Transporter Gene (5- HTTLPR/rs25531) Polymorphism with Comorbidities of Panic Disorder","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Association of Serotonin Transporter Gene (5- HTTLPR/rs25531) Polymorphism with Comorbidities of Panic Disorder","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["1336"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-08-31"},"publish_date":"2023-08-31","publish_status":"0","recid":"2000042","relation_version_is_last":true,"title":["Association of Serotonin Transporter Gene (5- HTTLPR/rs25531) Polymorphism with Comorbidities of Panic Disorder"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-10-17T01:55:30.247150+00:00"}