{"created":"2023-08-31T02:39:01.445948+00:00","id":2000043,"links":{},"metadata":{"_buckets":{"deposit":"2de4589f-5fcd-4904-8fd9-f38be86bd21d"},"_deposit":{"created_by":16,"id":"2000043","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"2000043"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000043","sets":["334:608:618:1336"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-03-24","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-03-24"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Following injury, skeletal muscle regenerates but fatty tissue accumulation is seen in aged muscle or muscular dystrophies. Fibro/adipogenic progenitors (FAPs) are key players in these events; however, the effect of primary cilia on FAPs remains unclear. Here, it is reported that genetic ablation of trichoplein (TCHP), a ciliary regulator, induces ciliary elongation on FAPs after injury, which promotes muscle regeneration while inhibiting adipogenesis. The defective adipogenic differentiation of FAPs is attributed to dysfunction of cilia-dependent lipid raft dynamics, which is critical for insulin/Akt signaling. It is also found that interleukin (IL) 13 is substantially produced by intramuscular FAPs, which are upregulated by ciliary elongation and contribute to regeneration. Mechanistically, upon injury, long cilia excessively activate the IL33/ST2/JNK axis to enhance IL13 production, facilitating myoblast proliferation and M2 macrophage polarization. The results indicate that FAPs organize the regenerative responses to skeletal muscle injury via cilia-mediated insulin/Akt and ST2/JNK signaling pathways.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Department of Gastroenterology and Hepatology Mie University Graduate School of Medicine Tsu, Mie 514-8507, Japan","subitem_description_type":"Other"},{"subitem_description":"15p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"乙医学第1084号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/advs.202202632","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"ADVANCED SCIENCE,2022 Nov 14; 10(1): e2202632.に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_7_version_type_15":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuboi, Junya","creatorNameLang":"en"},{"creatorName":"ツボイ, ジュンヤ","creatorNameLang":"ja-Kana"},{"creatorName":"坪井, 順哉","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-03-24"}],"displaytype":"detail","filename":"2022DM0348.pdf","filesize":[{"value":"6.92MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2022DM0348","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/2000043/files/2022DM0348.pdf"},"version_id":"e7eadd5d-6857-4ce0-b70b-9ef3815f5c36"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adipogenesis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"fibro/adipogenic progenitors","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin 13","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin 33","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lipid raft","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"aprimary cilia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"skeletal muscle regeneration","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["1336"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-08-31"},"publish_date":"2023-08-31","publish_status":"0","recid":"2000043","relation_version_is_last":true,"title":["Cilia-Mediated Insulin/Akt and ST2/JNK Signaling Pathways Regulate the Recovery of Muscle Injury"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2023-10-17T01:55:31.781470+00:00"}