{"created":"2023-12-12T04:55:06.504678+00:00","id":2000179,"links":{},"metadata":{"_buckets":{"deposit":"0893fa0e-01d1-493e-9208-cd2246a1d625"},"_deposit":{"created_by":15,"id":"2000179","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000179"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000179","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000179","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-31","bibliographicIssueDateType":"Issued"}}]},"item_8_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"今中, 恭子","creatorNameLang":"ja"}]}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"心筋炎は、ウイルス感染に起因する自己免疫反応による疾患であるが、一部の症例は慢性化し拡張型心筋症に移行する　本研究では、ヒト心筋生検標本261例を解析して予後と対比し、CD3陽性細胞24/mm2以上を慢性心筋炎の組織診断基準とした。また、急性心筋炎生検30例生検検体を網羅的病原体検索システムにより解析し、Parvovirus B19、HHV-6Aが1例ずつ検出された。さらに、炎症慢性化の分子メカニズムを解析するために、組換えBCG（rBCG-MyHCα）投与によるマウス慢性心筋炎モデルを確立し、細胞外タンパクテネイシンCがリンパ管新生を抑制することにより炎症を持続させる可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Dilated cardiomyopathy (DCM) is a heterogeneous group of myocardial diseases. Chronic myocarditis has been hypothesized to be one of the causes of DCM. Chronic myocarditis needs to be distinguished from other types of DCM because immunosuppressive agents may control disease progression. At present, endomyocardial biopsy is the only way for diagnosis, however, it needs a clear immunohistological criteria. We have performed a nationwide multicenter study of biopsy prove chronic myocarditis. Our data have suggested CD3+ T-lymphocytes count in the biopsied samples may be a risk-stratifying marker for poor long-term outcome and CD3+ > 24/mm2 could be a threshold for chronic myocarditis. Furthermore, to identify pathophysiological mechanism involved in progression of chronic myocarditis, we have developed a novel mouse model of chronic myocarditis induced by recombinant bacille Calmette-Guerin (rBCG) expressing a CD4+ T-cell epitope of cardiac myosin heavy chain-alpha.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19H03442","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 恭子","creatorNameLang":"ja"},{"creatorName":"Imanaka-Yoshida, Kyoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"田尻, 和子","creatorNameLang":"ja"},{"creatorName":"Tajiri, Kazuko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"奥村, 貴裕","creatorNameLang":"ja"},{"creatorName":"Okumura, Takahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"廣江, 道昭","creatorNameLang":"ja"},{"creatorName":"Hiroe, Michiaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"宇都, 健太","creatorNameLang":"ja"},{"creatorName":"Uto, Kenta","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"俵, 功","creatorNameLang":"ja"},{"creatorName":"Tawara, Isao","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"鈴木, 忠樹","creatorNameLang":"ja"},{"creatorName":"Suzuki, Tadaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"長谷川, 秀樹","creatorNameLang":"ja"},{"creatorName":"Hasegawa, Hideki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-12"}],"filename":"2023RP0014.pdf","filesize":[{"value":"301 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000179/files/2023RP0014.pdf"},"version_id":"b20e03d4-dd7e-487e-baeb-7f985fd82f53"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"心筋炎","subitem_subject_scheme":"Other"},{"subitem_subject":"拡張型心筋症","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"拡張型心筋症における慢性炎症の病態メカニズムの解明と層別化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"拡張型心筋症における慢性炎症の病態メカニズムの解明と層別化","subitem_title_language":"ja"},{"subitem_title":"Elucidation of pathophysiological mechanism of chronic inflammation and risk stratification of dilated cardiomyopathy.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-12"},"publish_date":"2023-12-12","publish_status":"0","recid":"2000179","relation_version_is_last":true,"title":["拡張型心筋症における慢性炎症の病態メカニズムの解明と層別化"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T00:58:29.493809+00:00"}