{"created":"2023-12-12T05:24:18.577287+00:00","id":2000180,"links":{},"metadata":{"_buckets":{"deposit":"e4450286-0b08-43ce-aa32-a7171629cdec"},"_deposit":{"created_by":15,"id":"2000180","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000180"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000180","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000180","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-16","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"炎症関連発がんではDNA損傷および損傷細胞から放出される傷害関連分子パターン(DAMP)ががんの進展と炎症性微小環境の増悪に重要である。代表的なDAMPである核内タンパクHMGB1は、核内から細胞質への移行とがん遠隔転移状況が関連する可能性を肝吸虫感染胆管癌患者において示した。HMGB1阻害作用のあるグリチルリチンは潰瘍性大腸炎-大腸がんモデルマウスで大腸腫瘍数が減少し炎症関連分子が抑制された。上咽頭癌細胞のヌードマウスの皮下移植モデルにおいて、タウリンは有意に腫瘍重量を低下させ、アポトーシスとオートファジー関連分子の発現上昇が認められた。炎症関連発がんにおける化学予防剤の可能性が示された。","subitem_description_type":"Abstract"},{"subitem_description":"DNA damage and damage-associated molecular patterns (DAMPs) released from damaged cells are important for inflammation-related cancer progression. We found that a representative DAMP, nuclear protein HMGB1, was associated with cancer distant metastasis status in liver fluke-infested cholangiocarcinoma patients when it translocates from the nucleus to the cytoplasm. Glycyrrhizin, an HMGB1 inhibitor, reduced the number of colorectal tumors and suppressed inflammation-related molecules in a mouse model of ulcerative colitis-colorectal cancer. In a nude mouse xenograft of subcutaneously implanted nasopharyngeal carcinoma cells, taurine significantly reduced tumor weight and increased expression of apoptosis- and autophagy-related molecules. These results suggest the potential of chemopreventive agents in inflammation-related carcinogenesis.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19H03884","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"村田, 真理子","creatorNameLang":"ja"},{"creatorName":"MURATA, Mariko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"及川, 伸二","creatorNameLang":"ja"},{"creatorName":"Oikawa, Shinji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"翠川, 薫","creatorNameLang":"ja"},{"creatorName":"Midorikawa, Kaoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"有馬, 寧","creatorNameLang":"ja"},{"creatorName":"Arima, Yasushi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-12"}],"filename":"2023RP0016.pdf","filesize":[{"value":"272 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000180/files/2023RP0016.pdf"},"version_id":"697e3466-0672-4cac-94bf-a3dce7f02cf1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"がん","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"傷害関連分子パターン","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"オートファジー","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA損傷","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症関連発がんにおけるDAMPとオートファジーの役割の解明とがん予防への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症関連発がんにおけるDAMPとオートファジーの役割の解明とがん予防への応用","subitem_title_language":"ja"},{"subitem_title":"Roles of DAMP and autophagy in inflammation-related carcinogenesis and its application to cancer prevention","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-12"},"publish_date":"2023-12-12","publish_status":"0","recid":"2000180","relation_version_is_last":true,"title":["炎症関連発がんにおけるDAMPとオートファジーの役割の解明とがん予防への応用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T01:04:17.959122+00:00"}