{"created":"2023-12-12T23:57:06.424912+00:00","id":2000183,"links":{},"metadata":{"_buckets":{"deposit":"432bc192-f980-4781-ab9c-292b8c4675a3"},"_deposit":{"created_by":15,"id":"2000183","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000183"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000183","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000183","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-16","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腸管上皮オルガノイドを用いたin vitro実験系において、遺伝子組換え型可溶性トロンボモジュリン(rsTM)は オルガノイドの成長を有意に促進し、腸管上皮幹細胞と上皮細胞遺伝子群の発現を濃度依存的に上昇した。デキストラン硫酸ナトリウム（DSS）誘発大腸炎モデルを用いたin vivo実験において、rsTMはマウスの体重回復を促進し、組織学的にも腸炎抑制効果と延命効果を示すことが分かった。また、rsTMがLGR5陽性腸管上皮幹細胞の増殖と上皮分化を増強させ、粘膜治癒を促進することが確認された。","subitem_description_type":"Abstract"},{"subitem_description":"Recombinant soluble thrombomodulin markedly stimulated the growth of intestinal organoids, thereby increasing the surface areas and budding phenotypes of the organoids. A high dose rsTM treatment significantly improved the recovery of body weight, histological outcomes, colon length shortening, and prolonged the survival of mice with colitis. Importantly, rsTM significantly upregulated the LGR5-positive stem cell proliferation and epithelial differentiation both in intestinal organoids and in intestinal tissues in colitis.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K07479","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高娃, 阿栄","creatorNameLang":"ja"},{"creatorName":"Gaowa, Arong","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"川本, 英嗣","creatorNameLang":"ja"},{"creatorName":"Kawamoto, Eiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"朴, 恩正","creatorNameLang":"ja"},{"creatorName":"Park, Eun Jeong","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"島岡, 要","creatorNameLang":"ja"},{"creatorName":"Shimaoka, Motomu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-13"}],"filename":"2023RP0019.pdf","filesize":[{"value":"229 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000183/files/2023RP0019.pdf"},"version_id":"a216bc69-20ff-4bbd-992f-e5056d22289d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"上皮再生","subitem_subject_scheme":"Other"},{"subitem_subject":"粘膜治癒","subitem_subject_scheme":"Other"},{"subitem_subject":"トロンボモジュリン","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性腸疾患","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"炎症性腸疾患の粘膜治癒過程におけるトロンボモジュリンの作用機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"炎症性腸疾患の粘膜治癒過程におけるトロンボモジュリンの作用機序の解明","subitem_title_language":"ja"},{"subitem_title":"Effects of recombinant thrombomodulin on intestinal mucosal healing","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-13"},"publish_date":"2023-12-13","publish_status":"0","recid":"2000183","relation_version_is_last":true,"title":["炎症性腸疾患の粘膜治癒過程におけるトロンボモジュリンの作用機序の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T01:21:13.841017+00:00"}