{"created":"2023-12-13T00:38:31.419292+00:00","id":2000184,"links":{},"metadata":{"_buckets":{"deposit":"a9bab14d-5d75-41fa-a519-0a62027e7682"},"_deposit":{"created_by":15,"id":"2000184","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000184"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000184","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000184","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-10","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"癌組織内では酸性環境が癌進展を促進している可能性が示されている。乳癌細胞を酸性環境で培養すると細胞間が解離し上皮間葉移行が観察された。インテグリンαvβ6が上皮間葉移行に関与し、FAK/Srcのリン酸化を誘導していた。その下流のコルタクチンはリン酸化され、接着斑に集積し、コルタクチン陽性浸潤突起が形成され、浸潤能が亢進していた。マウス乳癌細胞株を酸性条件で培養し、マウス尾静脈から静注した時、転移巣は有意に多かった。酸性条件下の培養細胞やヒト乳癌組織で酸性環境分子マーカーのGLUT1などの発現増強が確認できた。組織マイクロアレイを用いて、これらの発現と患者の予後データとの対比を行っている。","subitem_description_type":"Abstract"},{"subitem_description":"An acidic environment in cancer tissues is supposed to promote cancer progression. Breast cancer cells cultured in an acidic medium caused epithelial-mesenchymal transition. Integrin αvβ6 and phosphorylation of FAK/Src were involved in the change. Cortactin phosphorylated in downstream of the kinases was accumulated in adhesion plaques. Formation of cortactin-positive invadepodia promoted cancer cell invasion. Murine breast cancer cells, which were cultured in an acidic medium and injected into tail veins, formed significantly more metastatic foci in the lungs than those in the normal medium. In cancer cells cultured in the acidic condition in human breast cancer tissues, an enhanced expression of molecular markers for acidic condition, such as GLUT1, were confirmed. Now, we are going to clarify a relationship between expression of these markers and patient outcomes using the tissue microarrays.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度~2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K07662","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者(ヨミ)","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田, 利通","creatorNameLang":"ja"},{"creatorName":"Yoshida, Toshimichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"野呂, 綾","creatorNameLang":"ja"},{"creatorName":"Noro, Aya","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"石飛, 真人","creatorNameLang":"ja"},{"creatorName":"Ishitobi, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小塚, 祐司","creatorNameLang":"ja"},{"creatorName":"Kozuka, Yuji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-13"}],"filename":"2023RP0020.pdf","filesize":[{"value":"383 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000184/files/2023RP0020.pdf"},"version_id":"b4a3732b-5be9-499b-aa11-5319730fed54"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"癌細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"酸性環境","subitem_subject_scheme":"Other"},{"subitem_subject":"癌進展","subitem_subject_scheme":"Other"},{"subitem_subject":"癌転移","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がん組織で起きる酸性微小環境が癌進展を促進する機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がん組織で起きる酸性微小環境が癌進展を促進する機序の解明","subitem_title_language":"ja"},{"subitem_title":"Acidic environment of cancer tissues promotes cancer progression","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-13"},"publish_date":"2023-12-13","publish_status":"0","recid":"2000184","relation_version_is_last":true,"title":["がん組織で起きる酸性微小環境が癌進展を促進する機序の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T01:24:06.513586+00:00"}