{"created":"2023-12-13T01:38:03.930847+00:00","id":2000187,"links":{},"metadata":{"_buckets":{"deposit":"32a31cc8-b847-4ac6-98b0-0ad5bb349f28"},"_deposit":{"created_by":15,"id":"2000187","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000187"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000187","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000187","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-16","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"CX3CR1 wild type (WT)および欠損マウスの骨髄細胞を放射線照射マウスに移植して骨髄キメラマウスを作成し、移植8週後からAOM/DSSによる傷害を3サイクル繰り返した。AOM投与開始から20週時点で、欠損キメラマウスはWTキメラマウスに比し、(1) 大腸腫瘤の数が少なく、(2) 大腸組織中のCX3CR1highマクロファージ数とTnfa, Il1b, Tgfb遺伝子発現が低く、(3) 血漿TNF-α、IL-1β、TGF-βも少なかった。CX3CR1highマクロファージは炎症下において炎症性及び非炎症性サイトカインを産生し、大腸腫瘤形成に関与している可能性がある。","subitem_description_type":"Abstract"},{"subitem_description":"We prepared bone marrow (BM) chimeric mice, which were reconstituted with BM cells derived from wild-type (WT) or C-X3-C motif chemokine receptor 1 (CX3CR1)-deficient mice. Azoxymethane/dextran sodium sulfate (AOM/DSS) treatment started 8 weeks after BM transplantation and the DSS treatment was repeated for three cycles. At 20 weeks after the initiation of AOM, in CX3CR1-deficient BM chimeric mice compared with in WT BM chimeric mice, (1) the number of colon tumors was significantly reduced, (2) the number of CX3CR1high macrophages in the colonic lamina propria and mRNA expression level of Tnfa, Il1b, and Tgfb in the colon tissue decreased, (3) serum levels of TNF-α, IL-1β, and TGF-β were significantly lower. Therefore, CX3CR1high macrophages derived from BM are thought to be associated with the development of colon tumors by the production of inflammatory and anti-inflammatory cytokines during the colon inflammation.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K08442","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"桝屋, 正浩","creatorNameLang":"ja"},{"creatorName":"Masuya, Masahiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-13"}],"filename":"2023RP0023.pdf","filesize":[{"value":"211 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000187/files/2023RP0023.pdf"},"version_id":"7f2a51b0-9423-4d6f-8e91-bcc6085e7201"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"単球","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"CX3CR1","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸炎関連大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"AOM/DSS","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"CX3CR1陽性単球の大腸炎関連大腸癌発症における分子病態生理学的役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CX3CR1陽性単球の大腸炎関連大腸癌発症における分子病態生理学的役割の解明","subitem_title_language":"ja"},{"subitem_title":"Molecular pathophysiological role of CX3CR1+ monocytes in the development of colitis-associated colon cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-13"},"publish_date":"2023-12-13","publish_status":"0","recid":"2000187","relation_version_is_last":true,"title":["CX3CR1陽性単球の大腸炎関連大腸癌発症における分子病態生理学的役割の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T01:39:00.410217+00:00"}