{"created":"2023-12-13T01:50:38.338890+00:00","id":2000188,"links":{},"metadata":{"_buckets":{"deposit":"728afb4c-6c31-4f2d-9129-bee511299c3a"},"_deposit":{"created_by":15,"id":"2000188","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000188"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000188","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000188","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-02","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"移植片対宿主病（GVHD）は造血細胞移植の重要な合併症である。近年、マクロファージ（MΦ）はM1（炎症性）とM2（抗炎症性）の2つのタイプに分けられた。そこで、M2ΦのGVHD抑制効果を検証した。まず、骨髄細胞をGM-CSFとM-CSFで培養することでM1（CD38陽性）とM2（CD206陽性）の誘導に成功した。それらを用いてマウスGVHDモデルで調べたところ、M2Φは有意にGVHDを抑制し、生存率の改善がみられた。臨床・病理学的GVHDスコアでも改善を確認できた。GVHDの抑制された臓器ではM2Φが優位に多く浸潤していた。以上からM2Φ細胞療法は今後GVHD抑制が期待される結果であった。","subitem_description_type":"Other"},{"subitem_description":"Graft-versus-host disease (GVHD) is an important complication of hematopoietic cell transplantation. In recent years, macrophages (MΦ) have been divided into two types: M1 (inflammatory) and M2 (anti-inflammatory). Therefore, we examined an GVHD suppression effect of M2Φ. First, we performed in inducing M1 (CD38 positive) and M2 (CD206 positive) by culturing bone marrow cells in GM-CSF and/or M-CSF. By using the murine GVHD model, M2Φ significantly suppressed GVHD and improved survival rate. Improvement was also confirmed in the clinical and pathological GVHD scores. In organs in which GVHD was suppressed, M2Φ was predominantly infiltrated. After all, M2Φ cell therapy is expected to suppress the GVHD on hematopoietic cell transplantation.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K08836","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"平山, 雅浩","creatorNameLang":"ja"},{"creatorName":"Hirayama, Masahiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岩本, 彰太郎","creatorNameLang":"ja"},{"creatorName":"Iwamoto, Shotaro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-13"}],"filename":"2023RP0024.pdf","filesize":[{"value":"75 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000188/files/2023RP0024.pdf"},"version_id":"0bab1230-9058-4aac-b2f3-70af53854290"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GVHD","subitem_subject_scheme":"Other"},{"subitem_subject":"造血細胞移植","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"単球","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"遺伝子改変マウスC/EBPβを用いた移植後慢性GVHDの病態解明と新規治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"遺伝子改変マウスC/EBPβを用いた移植後慢性GVHDの病態解明と新規治療","subitem_title_language":"ja"},{"subitem_title":"Elucidation of pathophysiology and novel treatment of chronic GVHD after transplantation using genetically modified mouse C / EBPb","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-13"},"publish_date":"2023-12-13","publish_status":"0","recid":"2000188","relation_version_is_last":true,"title":["遺伝子改変マウスC/EBPβを用いた移植後慢性GVHDの病態解明と新規治療"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T01:46:12.849385+00:00"}