{"created":"2023-12-13T02:35:05.849862+00:00","id":2000191,"links":{},"metadata":{"_buckets":{"deposit":"08b6c13b-a09d-4f0f-bfb6-04cc47ab07ce"},"_deposit":{"created_by":15,"id":"2000191","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000191"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000191","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000191","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06-01","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"別添の資料に詳細を記載させて頂いたが、クローン病癌化4症例で原発巣組織(PC)、ならびに腫瘍近傍炎症粘膜(CM)より採取したRNA later sampleから抽出したtotal RNAを用いて次世代シーケンスによる網羅的解析を外注にて施行し、得られた生データを解析し癌合併クローン病症例の癌組織で異常発現するmiRNAを同定した。候補miRNAとしては、癌合併クローン病症例の癌組織で異常発現亢進するものとして合計10のmiRNAが同定された。","subitem_description_type":"Abstract"},{"subitem_description":"Please see the attached files. We extracted RNA from tumor tissues and from adjacent normal mucosa form crohn disease (CD) associated cancer patients. Then we ordered miRNA microarray, and performed bioinformatic statistical analysis by using the raw data. Interestingly, we identified 10 dysregulated miRNAs (hsa-miR-144-3p、hsa-miR-193a-3p、hsa-miR-223-3p、 hsa-miR-24-1-5p、hsa-miR-4291、hsa-miR-4532、hsa-miR-486-5p、hsa-miR-1229-5p、hsa-miR-1268b、hsa-miR-3960) in tumor tissue of CD associated cancer patients.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K09215","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"荒木, 俊光","creatorNameLang":"ja"},{"creatorName":"Araki, Toshimitsu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"Yoiyama, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大北, 喜基","creatorNameLang":"ja"},{"creatorName":"Okita, Yoshiki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"内田, 恵一","creatorNameLang":"ja"},{"creatorName":"Uchida, Keiichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"井上, 幹大","creatorNameLang":"ja"},{"creatorName":"Inoue, Mikihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"近藤, 哲","creatorNameLang":"ja"},{"creatorName":"Kondo, Satoru","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-13"}],"filename":"2023RP0027.pdf","filesize":[{"value":"163 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000191/files/2023RP0027.pdf"},"version_id":"0f4febe0-4ebc-4f2f-8489-8b8fe483f5ad"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"クローン病","subitem_subject_scheme":"Other"},{"subitem_subject":"消化管癌","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"癌合併クローン病に対するmicroRNAによる非侵襲的診断マーカーの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"癌合併クローン病に対するmicroRNAによる非侵襲的診断マーカーの開発","subitem_title_language":"ja"},{"subitem_title":"Development of non-invasive detection marker for Crohn-disease associated cancer patients","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-13"},"publish_date":"2023-12-13","publish_status":"0","recid":"2000191","relation_version_is_last":true,"title":["癌合併クローン病に対するmicroRNAによる非侵襲的診断マーカーの開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T02:03:22.813299+00:00"}