{"created":"2023-12-13T04:05:18.441776+00:00","id":2000192,"links":{},"metadata":{"_buckets":{"deposit":"f0f900d8-b8c1-4ce0-afa8-018eec658aaf"},"_deposit":{"created_by":15,"id":"2000192","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000192"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000192","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000192","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-18","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"敗血症での全身性炎症反応もしくは免疫不全において樹状細胞の機能が組織ごとで変化する可能性に着目した。マウスの盲腸結紮穿刺の敗血症モデルを樹立し、全身系組織の脾臓組織と腸管粘膜組織の腸間膜リンパ節から分離した樹状の機能を調べた。その結果、脾臓と腸間膜リンパ節の樹状細胞は、T細胞活性化誘導の機能が異なる可能性を示した。また、敗血症において腸管上皮由来のエキソソームが炎症性腸疾患マウスの炎症性サイトカイン分子の発現を抑制し局所での炎症を制御する可能性を確認した。特に、エキソソームのマイクロRNAが、腸管組織のTNF-alphaとIL-17Aの発現制御に働く可能性を報告した。","subitem_description_type":"Abstract"},{"subitem_description":"We have tested a possibility that functions of dendritic cells (DCs) are altered in sepsis, especially between different immune tissues. Using a sepsis model of cecal ligation and puncture (CLP), DCs were isolated from spleen and mesenteric lymph nodes (MLNs) and subjected to analyzing induction of T-cell activation. We have found that spleen DCs and MLN DCs display different activities in eliciting T cell immune responses (Darkwah et al. 2019Biomedicines). In addition, we examined if intestinal epithelium-derived luminally released exosomes exhibit the capacity in regulating expressions of proinflammatory cytokines. As a result, we found that some of functional miRNAs were supposed to possess an ability to suppress expressions of TNF-alpha and IL-17A (Appiah et al. 2020 International Journal of Molecular Sciences).","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K09392","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"朴, 恩正","creatorNameLang":"ja"},{"creatorName":"PARK, Eun Jeong","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"川本, 英嗣","creatorNameLang":"ja"},{"creatorName":"Kawamoto, Eiji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"島岡, 要","creatorNameLang":"ja"},{"creatorName":"Shimaoka, Motomu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"住吉, 美穂","creatorNameLang":"ja"},{"creatorName":"Sumiyoshi, Miho","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-13"}],"filename":"2023RP0029.pdf","filesize":[{"value":"297 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000192/files/2023RP0029.pdf"},"version_id":"642d8ef6-1a76-4230-aae1-2796f6c8f3cf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"腸管粘膜免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"腸管上皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"エキソソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞接着","subitem_subject_scheme":"Other"},{"subitem_subject":"インテグリン","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"敗血症","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"敗血症における腸管上皮エキソソームによるパラクライン的炎症制御作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"敗血症における腸管上皮エキソソームによるパラクライン的炎症制御作用","subitem_title_language":"ja"},{"subitem_title":"Study of the anti-inflammatory roles of the exosomes from intestinal epithelial cells in sepsis via a paracrine effect","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-13"},"publish_date":"2023-12-13","publish_status":"0","recid":"2000192","relation_version_is_last":true,"title":["敗血症における腸管上皮エキソソームによるパラクライン的炎症制御作用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T02:17:55.805152+00:00"}