{"created":"2023-12-13T05:08:46.213145+00:00","id":2000194,"links":{},"metadata":{"_buckets":{"deposit":"94550803-8d84-408d-8406-031e67edaf84"},"_deposit":{"created_by":15,"id":"2000194","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000194"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000194","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000194","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-20","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、前立腺癌の進行リスクは、肥満度に比例するという報告などを基に、前立腺癌細胞と脂肪細胞の相互作用に着目し、in vitro培養系で、脂肪細胞により誘導される前立腺癌細胞のmicroRNAの発現および機能解析を行った。脂肪細胞由来の培養液が、前立腺癌細胞の増殖、移動、浸潤能に影響を与え、前立腺細胞株により異なるmicroRNA発現パターンを示し、抽出したmiR-5787が増殖能や移動能に関与することを認めた。これらより、microRNA発現制御を介して、脂肪細胞が前立腺癌細胞に影響を与えることを証明した。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we focused on the interaction between prostate cancer cells and adipocytes based on reports about the relationship between the risk of prostate cancer progression and the degree of obesity, and analyzed microRNA expression and function in prostate cancer cells induced by adipocytes in an in vitro culture system. We found that adipocyte-conditioned medium affected the proliferation, migration, and invasion of prostate cancer cells, and that different prostate cell lines showed different microRNA expression patterns, indicating that the extracted miR-5787 was involved in proliferation and migration potential. From these results, we proved that adipocytes affect prostate cancer cells through the regulation of microRNA expression.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K09708","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡邉, 昌俊","creatorNameLang":"ja"},{"creatorName":"Watanabe, Masatoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"上村, 博司","creatorNameLang":"ja"},{"creatorName":"Uemura, Hiroji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"石井, 健一朗","creatorNameLang":"ja"},{"creatorName":"Ishii, Kenichiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-13"}],"filename":"2023RP0031.pdf","filesize":[{"value":"89 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000194/files/2023RP0031.pdf"},"version_id":"9f267eb6-4513-419a-9fa0-ccbc5fd659a5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"前立腺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"microRNA発現からみた脂肪細胞の前立腺癌細胞への作用解析とその臨床応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"microRNA発現からみた脂肪細胞の前立腺癌細胞への作用解析とその臨床応用","subitem_title_language":"ja"},{"subitem_title":"Analysis of the effects of adipocytes on prostate cancer cells from the viewpoint of microRNA expression and its clinical application","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-13"},"publish_date":"2023-12-13","publish_status":"0","recid":"2000194","relation_version_is_last":true,"title":["microRNA発現からみた脂肪細胞の前立腺癌細胞への作用解析とその臨床応用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T02:24:00.114714+00:00"}