{"created":"2023-12-14T00:43:34.582867+00:00","id":2000199,"links":{},"metadata":{"_buckets":{"deposit":"7b61c715-addb-44a1-8f3d-849d00b586ca"},"_deposit":{"created_by":15,"id":"2000199","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000199"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000199","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000199","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-27","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大腸癌患者における術前血清miR-203発現とサルコペニアの指標であるPMIと顕著に負の相関を認め、さらには、miR-203発現高発現は骨間筋細胞において細胞増殖を抑制し、アポトーシスを誘導することを証明した。大腸癌患者における血清中miR-203高発現はmyopeniaのリスク評価として有用なバイオマーカーであり、miR-203がmyopeniaを抑制する治療ターゲットになり得る可能性が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we identified the expression of miR-203 was negatively correlated with PMI. Furthermore, overexpression of miR-203 inhibited cell proliferation and induced apoptosis in human skeletal muscle cells. Serum miR-203 expression could be used for risk assessment of myopenia, and miR-203 might be a novel therapeutic target for inhibition of myopenia in CRC.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K11665","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三枝, 晋","creatorNameLang":"ja"},{"creatorName":"Saigusa, Susumu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"Toiyama, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"奥川, 喜永","creatorNameLang":"ja"},{"creatorName":"Okugawa, Yoshinaga","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"藤川, 裕之","creatorNameLang":"ja"},{"creatorName":"Fujikawa, Hiroyuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"kusunoki, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"三木, 誓雄","creatorNameLang":"ja"},{"creatorName":"Miki, Chikao","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-14"}],"filename":"2023RP0036.pdf","filesize":[{"value":"236 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000199/files/2023RP0036.pdf"},"version_id":"e931ba27-60ac-495f-861e-bd889e6083fb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"サルコペニア","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸癌Sarocopenia発症のエピゲノム機序解明と新たなバイオマーカーの開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌Sarocopenia発症のエピゲノム機序解明と新たなバイオマーカーの開発","subitem_title_language":"ja"},{"subitem_title":"Elucidating epigenome mechanism of Sarcopenia and development of new biomarkers in colorectal cancer.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-14"},"publish_date":"2023-12-14","publish_status":"0","recid":"2000199","relation_version_is_last":true,"title":["大腸癌Sarocopenia発症のエピゲノム機序解明と新たなバイオマーカーの開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T02:44:13.065947+00:00"}