{"created":"2023-12-14T01:05:44.864593+00:00","id":2000201,"links":{},"metadata":{"_buckets":{"deposit":"ded51184-4dca-484f-89d5-416c6cddedda"},"_deposit":{"created_by":15,"id":"2000201","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000201"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000201","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000201","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-14","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、マトリセルラー蛋白の１つであるテネイシンCが神経細胞アポトーシスを介し、てんかん原性獲得に寄与することを示唆する所見は得られなかった。しかし、血小板由来増殖因子受容体の活性化が神経細胞アポトーシスを介し、てんかん原性獲得に寄与していることを示唆する所見が得られ、その抑制薬により神経細胞アポトーシスの誘導は抑制された。血小板由来増殖因子受容体阻害薬の一部は既に臨床で用いられているので、臨床応用への道が容易に開ける可能性がある。本研究の成果は今後の更なる研究を促進し、新たなてんかん治療薬の開発へと発展していく可能性がある。","subitem_description_type":"Abstract"},{"subitem_description":"This study failed to demonstrate that a matricellular protein tenascin-C contributes to epileptogenesis via neuronal apoptosis. However, it is revealed that activation of platelet-derived growth factor receptor (PDGFR) caused neuronal apoptosis, possibly leading to the development of epileptogenesis, while a PDGFR antagonist inhibited neuronal apoptosis. As a PDGFR antagonist is clinically available, it may be easy to apply it to clinical practice. This study may enhance further studies, leading to the development of new anti-epileptic therapies.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K18422","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"市川, 尚己","creatorNameLang":"ja"},{"creatorName":"Ichikawa, Naoki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-14"}],"filename":"2023RP0039.pdf","filesize":[{"value":"179 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000201/files/2023RP0039.pdf"},"version_id":"4e003e53-34cc-4d34-8f1b-2b4bf28f3ec6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"てんかん","subitem_subject_scheme":"Other"},{"subitem_subject":"テネイシンC","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"テネイシンCに着目したてんかん原性獲得過程の病態解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"テネイシンCに着目したてんかん原性獲得過程の病態解明","subitem_title_language":"ja"},{"subitem_title":"Exploration of epileptogenetic mechanisms focusing on tenascin-C","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-14"},"publish_date":"2023-12-14","publish_status":"0","recid":"2000201","relation_version_is_last":true,"title":["テネイシンCに着目したてんかん原性獲得過程の病態解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T02:49:57.954325+00:00"}