{"created":"2023-12-14T01:24:55.195233+00:00","id":2000202,"links":{},"metadata":{"_buckets":{"deposit":"6c4095f5-8488-4349-93ff-6caf1f502adc"},"_deposit":{"created_by":15,"id":"2000202","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000202"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000202","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000202","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-17","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、ホスホリパーゼC（PLC）εの一次線毛退縮における機能解析を通じて、増殖シグナルによる一次線毛が退縮する分子機構の全容解明を目指した。PLCεは血清中のリゾホスファチジン酸（LPA）により活性化され、カルシウムオシレーションを起こすことが明らかとなった。また、AktやMAPKなどの増殖シグナルの持続的活性化もPLCεが担っていることが分かった。カルシウムイオノフォアによる持続的なカルシウムシグナルは一次線毛を退縮させることに十分であり、PLCεは受容体直下でこの機能を果たすと考えられた。今後、カルシウムシグナルの標的基質について検討する必要がある。","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we aimed to elucidate the molecular mechanism of primary cilia disassembly induced by proliferation signals through analyzing the function of phospholipase C(PLC) ε. PLCε was activated by lysophosphatidic acid (LPA) in serum and induced calcium oscillation. PLCε was also responsible for the sustained activation of proliferation signals such as Akt and MAPK. Because sustained calcium signaling by calcium ionophores was sufficient to disassemble primary cilia, PLCε was suggested to play a role in this function downstream of the receptor. Further studies are required to identify the substrates for calcium signaling.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2021年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K16105","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"稲葉, 弘哲","creatorNameLang":"ja"},{"creatorName":"Inaba, Hironori","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-14"}],"filename":"2023RP0040.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000202/files/2023RP0040.pdf"},"version_id":"2cb7e36d-0786-461d-9b3e-6d4ff3049cac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"一次線毛","subitem_subject_scheme":"Other"},{"subitem_subject":"PLCε","subitem_subject_scheme":"Other"},{"subitem_subject":"カルシウムシグナル","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞周期","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ホスホリパーゼCεによる一次線毛退縮制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ホスホリパーゼCεによる一次線毛退縮制御機構の解明","subitem_title_language":"ja"},{"subitem_title":"Analyses of the role of phospholipase C epsilon in the primary cilia disassembly","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-14"},"publish_date":"2023-12-14","publish_status":"0","recid":"2000202","relation_version_is_last":true,"title":["ホスホリパーゼCεによる一次線毛退縮制御機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T02:55:13.689424+00:00"}