{"created":"2023-12-14T01:39:31.339049+00:00","id":2000203,"links":{},"metadata":{"_buckets":{"deposit":"24669abd-09cb-48f0-bab8-07c055050780"},"_deposit":{"created_by":15,"id":"2000203","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000203"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000203","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000203","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-26","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"癌細胞の転移には癌細胞形態の変化が必要であり、柔軟性が高い細胞は転移を形成しやすいため、柔軟性の低下は転移の抑制に繋がると考えられる。細胞の柔軟性を細胞の剛性と捉え、マウス骨肉腫細胞の高肺転移株であるLM8を用いて、原子間力顕微鏡による細胞剛性を増幅させる薬物のスクリーニング、マウス肺転移モデルによる転移抑制効果の検討を行った。Na＋遮断薬、K＋遮断薬、Ca+遮断薬、Gap junction遮断薬の中で、Gap junction遮断薬であり消化性潰瘍治療薬であるカルベノキソロンは、細胞増殖を抑制せず、細胞の剛性を上昇することで肺転移を抑制した。","subitem_description_type":"Abstract"},{"subitem_description":"Cancer metastasis needs cell shape deformity. It is thought that highly deformable cancer cells have a highly metastatic phenotype. Experimentally, deformability was regarded as cell stiffness. We hypothesized that upregulation of cell stiffness inhibited lung metastasis. In this study, drug screening was performed based on cell stiffness evaluated by atomic force microscopy and lung metastasis in vivo mouse model. In the Na＋, K＋, Ca+ channel blocker and Gap junction blocker, carbenoxolone (gap junction inhibitor and drug for gastric ulcer) inhibited lung metastasis in vivo via upregulation of cell stiffness.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2021年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K18062","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"喜多, 晃司","creatorNameLang":"ja"},{"creatorName":"Kita, Kouji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-14"}],"filename":"2023RP0041.pdf","filesize":[{"value":"620 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000203/files/2023RP0041.pdf"},"version_id":"f01a4e1d-cf61-40f1-92a8-6b337372809d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"転移","subitem_subject_scheme":"Other"},{"subitem_subject":"硬さ","subitem_subject_scheme":"Other"},{"subitem_subject":"剛性","subitem_subject_scheme":"Other"},{"subitem_subject":"原子間力顕微鏡","subitem_subject_scheme":"Other"},{"subitem_subject":"アクチン濃度","subitem_subject_scheme":"Other"},{"subitem_subject":"骨肉腫","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"細胞剛性に着目した転移抑制薬スクリーニング","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞剛性に着目した転移抑制薬スクリーニング","subitem_title_language":"ja"},{"subitem_title":"Screening of anti-metastatic agent based on cell stiffness","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-14"},"publish_date":"2023-12-14","publish_status":"0","recid":"2000203","relation_version_is_last":true,"title":["細胞剛性に着目した転移抑制薬スクリーニング"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-20T04:15:29.562566+00:00"}