{"created":"2023-12-14T02:39:08.536999+00:00","id":2000206,"links":{},"metadata":{"_buckets":{"deposit":"c4a499d9-bd9a-4a3d-aacd-13264cb09a25"},"_deposit":{"created_by":15,"id":"2000206","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000206"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000206","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000206","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"難治性食道癌に有用なCAR-T療法を開発するために、臨床試験で細胞輸注されたTCR遺伝子導入T細胞（TCR-T）のフェノタイプ解析、免疫機能解析、トランスクリプトーム解析（糖代謝・脂肪代謝関連遺伝子発現解析を含む）を網羅的に行い、臨床試験におけるin vivo持続性、臨床効果に関連する因子を探索した。サイトカイン放出症候群（CRS）病態にはTCR-T輸注後の宿主由来のサイトカインが関与し、輸注TCR-T（製造T細胞）の分化形質が有意に関係していた。また、輸注後のTCR-T形質(CD39, CD244)と臨床反応が関与することが推察された。","subitem_description_type":"Abstract"},{"subitem_description":"To develop a CAR-T therapy for refractory esophageal cancer, we comprehensively analyzed the phenotype, immune function, and transcriptome (including gene expression analysis related to glucose and fat metabolism) of TCR-gene transduced T cells infused in clinical trials to identify factors associated with in vivo persistence and clinical efficacy. Factors associated with in vivo persistence and clinical efficacy were explored, and subpopulations selected. The CRS (cytokine release syndrome) pathogenesis involved host-derived cytokines after TCR-T infusion and was significantly related to the differentiation traits of infused TCR-T (manufactured T cells). It was also inferred that TCR-T traits (CD39, CD244) and clinical response (CRS, tumor shrinkage) were involved after infusion.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(挑戦的研究(萌芽))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K22655","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"影山, 愼一","creatorNameLang":"ja"},{"creatorName":"Kageyama, Shinichi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"宮原, 慶裕","creatorNameLang":"ja"},{"creatorName":"Miyahara, Yoshihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"加藤, 琢磨","creatorNameLang":"ja"},{"creatorName":"Kato, Takuma","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-14"}],"filename":"2023RP0044.pdf","filesize":[{"value":"234 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000206/files/2023RP0044.pdf"},"version_id":"41d10112-7425-45ba-8277-15780bcd5707"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"食道癌","subitem_subject_scheme":"Other"},{"subitem_subject":"がん免疫療法","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞治療","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"難治性食道癌に有効なCAR-T療法のための最適なT細胞選択","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"難治性食道癌に有効なCAR-T療法のための最適なT細胞選択","subitem_title_language":"ja"},{"subitem_title":"T cell optimization for effective CAR-T cell therapy to refractory esophageal cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-14"},"publish_date":"2023-12-14","publish_status":"0","recid":"2000206","relation_version_is_last":true,"title":["難治性食道癌に有効なCAR-T療法のための最適なT細胞選択"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T02:00:43.943337+00:00"}