{"created":"2023-12-14T04:05:55.854908+00:00","id":2000207,"links":{},"metadata":{"_buckets":{"deposit":"c1b5cf5a-e30d-45d9-8d50-e1bfd6088d99"},"_deposit":{"created_by":15,"id":"2000207","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000207"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000207","sets":["334:627:1701929182893"]},"author_link":[],"control_number":"2000207","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-16","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"成体組織に存在する組織滞在型マクロファージは、胎仔期に存在する胚体外組織である卵黄嚢に由来し、造血幹細胞に依存せず末梢組織で自己複製していることが、近年の研究から明らかとされている。本研究課題では、組織滞在型マクロファージの、卵黄嚢における発生学的起源を探索し、最初期の組織滞在型マクロファージの元となるのは、造血幹細胞が出現する以前に存在し、胎仔型赤血球およびリンパ球・ミエロイド系譜を作り出す造血細胞であることを突き止めた。またマウス線維芽細胞からマクロファージを作る技術の開発を試み、組織滞在型マクロファージの表現型を有する細胞の作製に成功した。","subitem_description_type":"Abstract"},{"subitem_description":"Tissue-resident macrophages are derived from the yolk sac tissue present during embryonic period. It is known that tissue-resident macrophages self-renew independently from hematopoietic stem cells. However, it was not precisely known which type of hematopoietic cells in the yolk sac give rise to macrophage lineage cells. In this study, our analysis showed that the earliest hematopoietic cells that generate primitive erythroid cells and lympho-myeloid lineage cells are the initial source of macrophage lineage cells in the yolk sac. A technology that allows the development of macrophages from mouse fibroblasts was also developed based on the knowledges obtained from the analysis of yolk sac hematopoiesis.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K09950","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山根, 利之","creatorNameLang":"ja"},{"creatorName":"YAMANE, TOSHIYUKI","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山崎, 英俊","creatorNameLang":"ja"},{"creatorName":"YAMAZAKI, HIDETOSHI","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-14"}],"filename":"2023RP0045.pdf","filesize":[{"value":"555 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000207/files/2023RP0045.pdf"},"version_id":"2d39351c-461f-47b0-9fbe-6008592438a5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"造血発生","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫発生","subitem_subject_scheme":"Other"},{"subitem_subject":"卵黄嚢","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞分化","subitem_subject_scheme":"Other"},{"subitem_subject":"リプログラミング","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"組織滞在型マクロファージの起源の探索および人為的作製法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"組織滞在型マクロファージの起源の探索および人為的作製法の開発","subitem_title_language":"ja"},{"subitem_title":"Identification of tissue-resident macrophage progenitors and the development of reprogramming technology to induce the cells","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929182893"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-14"},"publish_date":"2023-12-14","publish_status":"0","recid":"2000207","relation_version_is_last":true,"title":["組織滞在型マクロファージの起源の探索および人為的作製法の開発"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T02:03:33.187930+00:00"}