{"created":"2023-12-15T01:57:10.517331+00:00","id":2000211,"links":{},"metadata":{"_buckets":{"deposit":"33b9e27b-dc0f-4897-bd32-b16f73ac534f"},"_deposit":{"created_by":15,"id":"2000211","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000211"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000211","sets":["631:636:1701929233389"]},"author_link":[],"control_number":"2000211","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-13","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大腸癌組織特異的に部位特異的なRNA hyper-editingを呈し、また増殖能や浸潤能・遊走能に関与する可能性が示唆された。また線維芽細胞とがん細胞の相互関係の中で、RNA editing調節に伴うがん進展を誘導する機序が考慮された。一方、潰瘍性大腸炎関連癌との相関では、今回測定したRNA editing部位はepigenetic clockを反映せず、今後の検討が必要であった。本研究に付随して、部位特異的なメチル化レベルを、非癌部直腸粘膜を用いて測定することで、潰瘍性大腸炎関連癌発症症例を精度が高く(AUC:0.84)同定可能である可能性が考慮された。","subitem_description_type":"Abstract"},{"subitem_description":"Our study showed that RNA editing was occurred tissue-specific pattern in colorectal cancer (CRC), and series of in vitro analysis revealed that RNA editing was deeply involved in disease development in CRC. In addition, intimate correlation between cancer cells and fibroblast cells via mechanism of RNA editing for CRC development in cancer microenvironments also clarified. In contrast, identified RNA editing cites did not correlated with aging factors in ulcerative colitis (UC) or UC-associated CRC, and further studies are need. Accompanied with this study, we successfully identified novel CpG site in DNA methylation level to detect patients with UC-CRC with high accuracy (AUC:0.84) via assessment of non-cancerous rectal mucosa.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K09169","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"奥川, 喜永","creatorNameLang":"ja"},{"creatorName":"Okugawa, Yoshinaga","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"Toiyama, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大北, 喜基","creatorNameLang":"ja"},{"creatorName":"Okita, Yoshiki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"荒木, 俊光","creatorNameLang":"ja"},{"creatorName":"Araki, Toshimitsu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-15"}],"filename":"2023RP0049.pdf","filesize":[{"value":"763 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000211/files/2023RP0049.pdf"},"version_id":"8086ad5f-20ed-40cf-9d53-32f60c4c8a2d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"潰瘍性大腸炎","subitem_subject_scheme":"Other"},{"subitem_subject":"大腸癌","subitem_subject_scheme":"Other"},{"subitem_subject":"メチル化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"大腸癌・潰瘍性大腸炎関連癌における後天的RNA修飾マーカーの有用性","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸癌・潰瘍性大腸炎関連癌における後天的RNA修飾マーカーの有用性","subitem_title_language":"ja"},{"subitem_title":"Clinical significance of RNA editing marker in patients with CRC and UC-CRC","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929233389"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-15"},"publish_date":"2023-12-15","publish_status":"0","recid":"2000211","relation_version_is_last":true,"title":["大腸癌・潰瘍性大腸炎関連癌における後天的RNA修飾マーカーの有用性"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T02:24:39.925908+00:00"}