{"created":"2023-12-15T02:47:24.415414+00:00","id":2000213,"links":{},"metadata":{"_buckets":{"deposit":"081af99d-1e45-4482-b169-6ddc49ed81ac"},"_deposit":{"created_by":15,"id":"2000213","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000213"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000213","sets":["631:636:1701929233389"]},"author_link":[],"control_number":"2000213","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究の目的は、1周産期侵襲のラットPAHの増悪効果、2肺血管平滑筋の細胞生物学的特性とゲノムワイドのDNAメチル化変化の解明である。方法は、1母胎・ 新生児ラットの周産期低酸素暴露侵襲による遠隔期のSugen/Hypoxiaラットの肺高血圧増悪効果、2周産期低酸素暴露後遠隔期の培養血管平滑筋細胞の増殖促進・ 細胞死抑制と関連したゲノムワイドDNAメチル化の解析である。結果では、周産期低酸素は、Sugen/Hypoxiaラットの生命予後、肺動脈圧、右室肥大、肺血管閉塞性病変を悪化させた。培養肺動脈血管平滑筋細胞は、増殖能、炎症性サイトカイン産生能を、更新し、関連したDNAメチル化を認めた。","subitem_description_type":"Abstract"},{"subitem_description":"The objectives of the study were 1) to elucidate the exacerbating effects of perinatal invasion on PAH in rats, and 2) to elucidate cell biological characteristics and genome-wide DNA methylation changes in pulmonary vascular smooth muscle. The methods were: 1) the exacerbating effect of perinatal hypoxic invasion of maternal and neonatal rats on pulmonary hypertension in Sugen/Hypoxia rats in the remote period, and 2) analysis of genome-wide DNA methylation in relation to accelerated proliferation and suppressed cell death in cultured vascular smooth muscle cells in the remote period after perinatal hypoxia exposure. Results showed that perinatal hypoxia worsened life expectancy, pulmonary artery pressure, right ventricular hypertrophy, and pulmonary vascular occlusive lesions in Sugen/Hypoxia rats. Cultured pulmonary artery vascular smooth muscle cells showed renewed proliferative capacity, inflammatory cytokine production capacity, and associated DNA methylation.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K17292","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大矢, 和伸","creatorNameLang":"ja"},{"creatorName":"Ohya, Kazunobu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-15"}],"filename":"2023RP0051.pdf","filesize":[{"value":"74 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000213/files/2023RP0051.pdf"},"version_id":"bb8943e0-c8c6-4945-a689-7e88586772b0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肺高血圧","subitem_subject_scheme":"Other"},{"subitem_subject":"肺動脈性肺高血圧","subitem_subject_scheme":"Other"},{"subitem_subject":"動物モデル","subitem_subject_scheme":"Other"},{"subitem_subject":"周産期刺激","subitem_subject_scheme":"Other"},{"subitem_subject":"周産期医学","subitem_subject_scheme":"Other"},{"subitem_subject":"DoHAD仮説","subitem_subject_scheme":"Other"},{"subitem_subject":"エピゲノム変化","subitem_subject_scheme":"Other"},{"subitem_subject":"DN Aメチレーション","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"周産期侵襲の肺動脈性肺高血圧の発症への関与：エピゲノムを介する分子機序","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"周産期侵襲の肺動脈性肺高血圧の発症への関与：エピゲノムを介する分子機序","subitem_title_language":"ja"},{"subitem_title":"Contribution of perinatal insults to the development of pulmonary arterial hypertension","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929233389"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-15"},"publish_date":"2023-12-15","publish_status":"0","recid":"2000213","relation_version_is_last":true,"title":["周産期侵襲の肺動脈性肺高血圧の発症への関与：エピゲノムを介する分子機序"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T02:34:51.100982+00:00"}