{"created":"2023-12-15T04:09:09.823454+00:00","id":2000214,"links":{},"metadata":{"_buckets":{"deposit":"932287c0-93dd-4ab8-a0c9-3a3a8affc117"},"_deposit":{"created_by":15,"id":"2000214","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000214"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000214","sets":["631:636:1701929233389"]},"author_link":[],"control_number":"2000214","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"【背景】αジストログリカン (DG) は糖鎖修飾を受け、細胞外マトリックス (ECM)蛋白と結合し、ECM環境を管理し、細胞増殖、分化、接着、遊走を調整する。【目的】αDGの糖鎖修飾異常の回復は、神経芽腫（NB）の増殖を抑制するかどうかを明らかにする。【結果】ヒトNB細胞株のなかにαDGの糖鎖修飾低下、ラミニン結合低下を呈する株があり、低下株と正常株の間でαDG糖鎖修飾関連遺伝子発現に差はなく、ribitol投与はSJ-N-JF株のαDGの糖鎖修飾低下を改善し、xenograftモデルにおいて腫瘍増大を抑制した。【結論】NBのαDG糖鎖修飾低下は腫瘍増殖に関連し治療標的になりうる。","subitem_description_type":"Abstract"},{"subitem_description":"Background: α-dystroglycan (DG) is glycosylated and binds to the extracellular matrix proteins, which can maintain the micro-environment. Objectives: To elucidate that restoration of hypoglycosy lated α-DG inhibits neuroblastoma (NB) cell proliferation. Results: Some of NB cell lines exhibited hypoglycosylation and low laminin binding capacity of α-DG. The genes involved in α-DG glycosylation were normally expressed. Supplementation of ribitol improved hypoglycosylation of α-DG in SJ-N-JF cells and repressed tumor growth in SJ-N-JF xenograft model. Conclusions : Restoration of hypoglycosylated α-DG can inhibit neuroblastoma (NB) cell proliferation.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K17855","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"米川, 貴博","creatorNameLang":"ja"},{"creatorName":"Yonekawa, Takahiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-15"}],"filename":"2023RP0052.pdf","filesize":[{"value":"163 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000214/files/2023RP0052.pdf"},"version_id":"1a2b3db8-797d-4923-95bd-761d835e9a9b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"αジストログリカン","subitem_subject_scheme":"Other"},{"subitem_subject":"糖鎖修飾","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞外マトリックス","subitem_subject_scheme":"Other"},{"subitem_subject":"神経芽腫","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Effect of LARGE1 systemic gene delivery by adeno-associated virus on metastatic potential in high-risk neuroblastoma","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of LARGE1 systemic gene delivery by adeno-associated virus on metastatic potential in high-risk neuroblastoma","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929233389"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-15"},"publish_date":"2023-12-15","publish_status":"0","recid":"2000214","relation_version_is_last":true,"title":["Effect of LARGE1 systemic gene delivery by adeno-associated virus on metastatic potential in high-risk neuroblastoma"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T02:37:08.038196+00:00"}