{"created":"2023-12-18T01:01:14.778849+00:00","id":2000218,"links":{},"metadata":{"_buckets":{"deposit":"b6aff77e-dd8a-4cf1-a57b-afced179e060"},"_deposit":{"created_by":15,"id":"2000218","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000218"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000218","sets":["631:636:1701929233389"]},"author_link":[],"control_number":"2000218","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-25","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"多血小板フィブリン(Platelet Rich Fibrin: PRF)は高濃度の成長因子を含んだフィブリン塊で、徐放性に優れるため様々な病態への治癒促進することが期待されている。我々はPRFのアキレス腱欠損に対する直接的な評価を動物モデルで行い、さらに腱修復に重要な役割を担うtenocyteに対する影響およびシグナル経路を特定することを目的に研究を行なった。結果、PRFはFGF受容体/Aktシグナルを介してtenocyteの増殖、TGF-β受容体/ Smad3を介してtenocyteを活性化させ、アキレス腱損傷治癒を促進することを見出した。","subitem_description_type":"Abstract"},{"subitem_description":"Platelet Rich Fibrin (PRF) is a fibrin mass containing high growth factors concentrations. It is expected to promote healing in various pathological conditions due to its sustained release properties. We evaluated PRF directly on Achilles tendon defects in an animal model. We aimed to identify its effect on tenocytes, which play an essential role in tendon repair, and the signaling pathways involved. We found that PRF promotes tenocyte proliferation via FGF receptor/Akt signaling and tenocyte activation via TGF-β receptor/Smad3 signaling to promote Achilles tendon injury healing.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2021年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K18029","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"千賀, 佳幸","creatorNameLang":"ja"},{"creatorName":"Senga, Yoshiyuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-18"}],"filename":"2023RP0056.pdf","filesize":[{"value":"158 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000218/files/2023RP0056.pdf"},"version_id":"b76ad657-8050-4589-bae8-f9a7e51daf87"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"多血小板フィブリン","subitem_subject_scheme":"Other"},{"subitem_subject":"PRF","subitem_subject_scheme":"Other"},{"subitem_subject":"アキレス腱","subitem_subject_scheme":"Other"},{"subitem_subject":"再生医療","subitem_subject_scheme":"Other"},{"subitem_subject":"成長因子","subitem_subject_scheme":"Other"},{"subitem_subject":"スポーツ外傷・障害","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アキレス腱損傷における多血小板フィブリンの影響とその分子学的メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アキレス腱損傷における多血小板フィブリンの影響とその分子学的メカニズムの解明","subitem_title_language":"ja"},{"subitem_title":"Thr effects of platelet-rich fibrin on Achilles tendon injury and tenocytes","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929233389"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-18"},"publish_date":"2023-12-18","publish_status":"0","recid":"2000218","relation_version_is_last":true,"title":["アキレス腱損傷における多血小板フィブリンの影響とその分子学的メカニズムの解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T02:48:25.827337+00:00"}