{"created":"2023-12-18T01:10:58.742445+00:00","id":2000219,"links":{},"metadata":{"_buckets":{"deposit":"6c276209-216a-4205-afad-4ea6ad1e7ac4"},"_deposit":{"created_by":15,"id":"2000219","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000219"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000219","sets":["631:636:1701929233389"]},"author_link":[],"control_number":"2000219","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-17","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"V2受容体拮抗薬であるトルバプタンは腎集合管でV2受容体を阻害することで水利尿作用を発揮する。AngII刺激下でアルドステロン産生を増加させたヒト副腎皮質由来の培養細胞であるH295R細胞およびラットモデルを用いた実験からトルバプタンがV2R非依存性にアルドステロン濃度上昇およびアルドステロン合成酵素であるCYP11B2タンパク発現量増加を抑制することが確認された。これらの機序として、トルバプタンがCYP11B2のmRNA発現量を抑制することなく蛋白発現量を抑制し、DDIT3蛋白発現の増加とeIF2αのリン酸化亢進をきたしたことから、小胞体ストレス応答を介した蛋白合成過程への関与が示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Tolvaptan, a V2 receptor antagonist, exerts its water diuretic effect by inhibiting V2 receptors in the renal collecting ducts. Experiments using H295R cells, cultured cells derived from the human adrenal cortex and rat models with increased aldosterone production under AngII stimulation, have shown that Tolvaptan suppressed the increase in aldosterone concentration and protein expression of CYP11B2, an aldosterone synthase, by a V2R-independent manner. In addition, tolvaptan suppressed protein expression without suppressing CYP11B2 mRNA expression, and increased DDIT3 protein expression and phosphorylation of eIF2α. These results suggest that tolvaptan could have attenuated CYP11B2 translation and subsequently inhibited the aldosterone biosynthesis, likely in part by promoting the UPR and subsequent inhibition of global protein translation.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K08066","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 正明","creatorNameLang":"ja"},{"creatorName":"Ito, Masaaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"土肥, 薫","creatorNameLang":"ja"},{"creatorName":"Dohi, Kaoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"岡本, 隆二","creatorNameLang":"ja"},{"creatorName":"Okamoto, Ryuji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-18"}],"filename":"2023RP0057.pdf","filesize":[{"value":"570 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000219/files/2023RP0057.pdf"},"version_id":"083ea152-2429-4888-ae13-64a45b2d52aa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"トルバプタン","subitem_subject_scheme":"Other"},{"subitem_subject":"アルドステロン","subitem_subject_scheme":"Other"},{"subitem_subject":"心不全","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"副腎アルドステロン産生に対するバゾプレシンV2受容体拮抗薬の新しい薬理作用の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"副腎アルドステロン産生に対するバゾプレシンV2受容体拮抗薬の新しい薬理作用の解明","subitem_title_language":"ja"},{"subitem_title":"Effects of Tolvaptan via vasopressin V2 receptor-independent pathway on adrenal aldosterone synthesis.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929233389"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-18"},"publish_date":"2023-12-18","publish_status":"0","recid":"2000219","relation_version_is_last":true,"title":["副腎アルドステロン産生に対するバゾプレシンV2受容体拮抗薬の新しい薬理作用の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T02:51:28.173231+00:00"}