{"created":"2023-12-18T05:01:26.043028+00:00","id":2000221,"links":{},"metadata":{"_buckets":{"deposit":"9cffcb66-247b-4b09-a70a-17d044e1ad24"},"_deposit":{"created_by":15,"id":"2000221","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000221"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000221","sets":["631:636:1701929233389"]},"author_link":[],"control_number":"2000221","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-23","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"子宮腺筋症は不妊・不育症に関与している。本研究では、ICRマウスを生後2日目～5日目にタモキシフェンを内服させ、妊娠15週以降には子宮内膜腺が筋層内に侵入した子宮腺筋症を認めた。子宮腺筋症患者の妊娠維持のため、PDE5阻害剤を内服させ血流改善を試みることで妊娠出産を期待し、本マウスの性成熟期にPDE5阻害剤を投与した。その結果、子宮筋層内の内膜腺の増加を認めた。本結果より、子宮筋層への血流増加による内膜腺の増生が考えられた。今後、本マウスを交配させ妊娠結果を検討していきたい。","subitem_description_type":"Abstract"},{"subitem_description":"Uterine adenomyosis is implicated in infertility and intensified. In this study, ICR mice were given tamoxifen intravenously on days 2-5 postnatal, and after 15 weeks of gestation, adenomyosis uteri with endometrial glands invading the uterine myometrium was observed. To maintain pregnancy in adenomyosis patients, PDE5 inhibitors were administered during sexual maturity in these mice in the hope of achieving pregnancy and delivery by attempting to improve blood flow by oral administration of PDE5 inhibitors. The results showed an increase in endometrial glands within the myometrium. These results suggest that the increase in blood flow to the myometrium may have resulted in the proliferation of endometrial glands. In the future, we would like to crossbreed these mice and study the pregnancy results.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2021年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K16797","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前沢, 忠志","creatorNameLang":"ja"},{"creatorName":"Maezawa, Tadashi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-18"}],"filename":"2023RP0059.pdf","filesize":[{"value":"157 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000221/files/2023RP0059.pdf"},"version_id":"62ddd3b5-2eab-4856-8df2-a905d262c333"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"子宮腺筋症","subitem_subject_scheme":"Other"},{"subitem_subject":"不妊症","subitem_subject_scheme":"Other"},{"subitem_subject":"不育症","subitem_subject_scheme":"Other"},{"subitem_subject":"PDE5阻害剤","subitem_subject_scheme":"Other"},{"subitem_subject":"タモキシフェン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"子宮腺筋症不妊に対するPDE5阻害薬の効果と酸化ストレスへの影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"子宮腺筋症不妊に対するPDE5阻害薬の効果と酸化ストレスへの影響","subitem_title_language":"ja"},{"subitem_title":"Relationship between the effects of PDE5 inhibitors and oxidative stress on infertility caused by adenomyosis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929233389"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-18"},"publish_date":"2023-12-18","publish_status":"0","recid":"2000221","relation_version_is_last":true,"title":["子宮腺筋症不妊に対するPDE5阻害薬の効果と酸化ストレスへの影響"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T02:59:57.490247+00:00"}