{"created":"2023-12-19T00:05:29.284064+00:00","id":2000223,"links":{},"metadata":{"_buckets":{"deposit":"8f2bdec3-9da9-4ef3-8ba3-82e03ed26703"},"_deposit":{"created_by":15,"id":"2000223","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000223"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000223","sets":["631:636:1701929233389"]},"author_link":[],"control_number":"2000223","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-17","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"mTORシグナルに着目し、ヒト胎盤におけるmTORシグナルの下流で働くps6とeIF-4の活性が、FGRに対してタダラフィルを投与した後にどのように変化するかを調べ、その作用メカニズムの解明を目指した。ps6およびeIF-4の発現は、それぞれウェスタンブロッティングおよび酵素結合免疫吸着法により調べた。ps6と eIF-4 のレベルは、FGR 胎盤で対照胎盤よりも有意に高かったが、タダラフィル投与後は対照レベルまで減少した。タダラフィルは、FGR胎盤のps6、eIF-4Eのレベルをコントロール胎盤で観察されるレベルまで回復させ、FGRの治療戦略として有望であることが示唆された。","subitem_description_type":"Abstract"},{"subitem_description":"Focusing on mTOR signaling, we investigated how the activities of ps6 and eIF-4, which act downstream of mTOR signaling in human placenta, are altered after tadalafil administration to FGR to elucidate their mechanisms of action. The levels of ps6 and eIF-4 were significantly higher in FGR placentas than in control placentas, but decreased to control levels after tadalafil administration. Tadalafil restored the levels of ps6 and eIF-4E in FGR placentas to the levels observed in control placentas, suggesting that it is a promising therapeutic strategy for FGR.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K18638","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 博明","creatorNameLang":"ja"},{"creatorName":"Tanaka, Hiroaki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-19"}],"filename":"2023RP0061.pdf","filesize":[{"value":"83 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000223/files/2023RP0061.pdf"},"version_id":"7bb137db-c9e6-4353-afc8-a45f48a8c3ac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胎児発育不全","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胎児発育不全の改善に果たすタダラフィルの作用機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胎児発育不全の改善に果たすタダラフィルの作用機序の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the mechanism of tadalafil for fetal growth restriction","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929233389"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-19"},"publish_date":"2023-12-19","publish_status":"0","recid":"2000223","relation_version_is_last":true,"title":["胎児発育不全の改善に果たすタダラフィルの作用機序の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T04:10:08.995566+00:00"}