{"created":"2023-12-19T00:14:36.965744+00:00","id":2000224,"links":{},"metadata":{"_buckets":{"deposit":"596da294-c2c8-4604-8f2b-a0b125471e04"},"_deposit":{"created_by":15,"id":"2000224","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000224"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000224","sets":["631:636:1701929233389"]},"author_link":[],"control_number":"2000224","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"胎児発育不全(FGR)において、PDE5阻害薬:タダラフィルの経母体投与を行った胎児の、投与前後の胎児胎盤血流の変化を検討した。従来型治療群45例と、タダラフィル治療群において、胎児推定体重が-2.0SD以下の症例では、臍帯動脈PIは治療開始1週間後有意に減少していた。MRIの位相contrast法にて、タダラフィル投与FGR群6例と、週数をマッチさせた正常妊婦6例の両群に、2回子宮動脈血流量の測定を行ったところ、タダラフィル投与FGR群では内服後1週間で子宮動脈血流量が有意に増加していた。","subitem_description_type":"Abstract"},{"subitem_description":"The changes in feto-placental blood flow before and after administration of tadalafil, a PDE5 inhibitor, for fetal growth restriction (FGR) were investigated. In 45 patients in the conventional treatment group and in the tadalafil treatment group, the estimated fetal weight was -2.0SD or less, and the umbilical artery PI decreased significantly 1 week after the start of treatment. Uterine arterial blood flow was measured twice in both the tadalafil-administered FGR group (6 patients) and the gestational age-matched normal pregnant women (6 patients) by the phase contrast method of MRI. In the tadalafil-administered FGR group, uterine arterial blood flow was significantly increased 1 week after oral administration.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度~2021年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K18694","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者(ヨミ)","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"真木, 晋太郎","creatorNameLang":"ja"},{"creatorName":"Maki, Shintaro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-19"}],"filename":"2023RP0062.pdf","filesize":[{"value":"80 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000224/files/2023RP0062.pdf"},"version_id":"19ac52b8-d95f-4065-8b96-999f95dc5a4c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胎児発育不全","subitem_subject_scheme":"Other"},{"subitem_subject":"PDE5阻害薬","subitem_subject_scheme":"Other"},{"subitem_subject":"タダラフィル","subitem_subject_scheme":"Other"},{"subitem_subject":"胎盤機能不全","subitem_subject_scheme":"Other"},{"subitem_subject":"胎児-胎盤循環","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胎盤機能不全におけるタダラフィル投与による病態改善機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胎盤機能不全におけるタダラフィル投与による病態改善機序の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of pathological improvement mechanism by tadalafil administration in placental dysfunction","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929233389"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-19"},"publish_date":"2023-12-19","publish_status":"0","recid":"2000224","relation_version_is_last":true,"title":["胎盤機能不全におけるタダラフィル投与による病態改善機序の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T04:12:06.154403+00:00"}