{"created":"2023-12-19T00:33:25.829451+00:00","id":2000225,"links":{},"metadata":{"_buckets":{"deposit":"80892791-d8a8-4720-9d25-fd31fca9e4d2"},"_deposit":{"created_by":15,"id":"2000225","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000225"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000225","sets":["631:636:1701929233389"]},"author_link":[],"control_number":"2000225","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"誘発電位のひとつであるChange-N1のプレパルス抑制を用いて統合失調症の神経認知の解明を目指した。健常者を対象とし、統合失調症関連遺伝子であるCOMT遺伝子多型とChange-N1のプレパルス抑制の関連を明らかにした。また、健常者と比べて統合失調症患者においてはChange-N1振幅低下とそのプレパルス抑制の減弱がみられた。誘発電位を用いて統合失調症における変化応答と抑制系の障害を明らかにできた。聴性定常反応も突然の音特性変化による聴性定常反応の位相速化は音圧変化量に影響される。この聴性定常反応の位相速化も変化応答を示唆する所見であり、今後の統合失調症研究への応用が期待される。","subitem_description_type":"Abstract"},{"subitem_description":"We attempted to clarify neurocognition in schizophrenia by using an evoked potential, i.e., Change-N1, and its prepulse inhibition (PPI). Healthy Met carrier subjects showed significantly greater PPI of Change-N1 compared to healthy Val/Val subjects with the catechol-O-methyltransferase Val/158Met polymorphism, which is one of the candidate genes for schizophrenia. The Change-N1 amplitude and its PPI in subjects with schizophrenia were weaker than those in the healthy subjects. These results might indicate a deficit of change detection and the inhibitory system in schizophrenia. An abrupt change in sound pressure also transiently accelerates a phase of the auditory steady-state response (ASSR). The degree of this phase acceleration depended on the magnitude of the change in sound pressure. Further studies of patients with schizophrenia that uses the phase acceleration of ASSR which might be an additional index of change detection are needed.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2017年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"17K10296","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"元村, 英史","creatorNameLang":"ja"},{"creatorName":"MOTOMURA, EISHI","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"前田, 正幸","creatorNameLang":"ja"},{"creatorName":"MAEDA, MASAYUKI","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"乾, 幸二","creatorNameLang":"ja"},{"creatorName":"INUI, KOJI","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"谷井, 久志","creatorNameLang":"ja"},{"creatorName":"TANII, HISASHI","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-19"}],"filename":"2023RP0063.pdf","filesize":[{"value":"207 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000225/files/2023RP0063.pdf"},"version_id":"0576be1e-9594-4d80-a969-49e873568eae"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"統合失調症","subitem_subject_scheme":"Other"},{"subitem_subject":"神経認知","subitem_subject_scheme":"Other"},{"subitem_subject":"誘発脳活動","subitem_subject_scheme":"Other"},{"subitem_subject":"変化応答","subitem_subject_scheme":"Other"},{"subitem_subject":"プレパルス抑制","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"統合失調症の認知障害の解明-変化検出とその抑制に着目して","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"統合失調症の認知障害の解明-変化検出とその抑制に着目して","subitem_title_language":"ja"},{"subitem_title":"Investigation of cognitive deficits in schizophrenia, focusing on change detection and its inhibition","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929233389"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-19"},"publish_date":"2023-12-19","publish_status":"0","recid":"2000225","relation_version_is_last":true,"title":["統合失調症の認知障害の解明-変化検出とその抑制に着目して"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T04:15:26.748648+00:00"}