{"created":"2023-12-21T05:11:40.644173+00:00","id":2000263,"links":{},"metadata":{"_buckets":{"deposit":"f21d626f-ff4a-4a18-9d65-f1d7aae1945a"},"_deposit":{"created_by":15,"id":"2000263","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000263"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000263","sets":["366:680:1701929300332"]},"author_link":[],"control_number":"2000263","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-24","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"難治性の神経機能障害に対する神経補綴の確立には、脳などの対象組織内の時空間的な神経活動を精密に駆動/制御する手法・技術が求められている。本研究では、1)先行開発の多チャンネル神経刺激モジュールを制御するハードウェアシステムと、このシステムによって生成される時空間パターン刺激の設計を行うためのGUIソフトウェアを開発した。２）脳切片試料を用いたミリ秒分解能の高速膜電位イメージング実験により、脳皮質内の単一微小電極刺激に誘発される時空間的な神経活動の特性とその生理学的メカニズムについて、さらに、複数微小電極からの刺激に対する神経応答の時空間的な独立性と非線形加法性について新たな知見を得た。","subitem_description_type":"Abstract"},{"subitem_description":"In order to establish neural prostheses for patients suffering from intractable neural dysfunctions, methods and techniques for precisely driving/controlling the spatiotemporal neural activity in the target neural tissue such as the cerebral cortex are required. In the present study, 1) we developed a hardware system that controls our previously developed multi-channel neural stimulator, and also a GUI software that supports the designing of the spatiotemporal patterns of stimuli generated by this system, 2) through the experiments with the voltage-sensitive dye fast imaging at millisecond temporal resolution in the cerebral tissue slices, we obtained new findings on spatiotemporal properties and physiological mechanisms of the neural activity induced by stimulation with the intra-cortical single microelectrode, and also on independence and nonlinear additivity of the neural responses to stimulation with multiple microelectrodes.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2018年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"18K12059","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"林田, 祐樹","creatorNameLang":"ja"},{"creatorName":"Hayashida, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"末松, 尚史","creatorNameLang":"ja"},{"creatorName":"Suematsu, Naofumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"八木, 哲也","creatorNameLang":"ja"},{"creatorName":"Yagi, Tetsuya","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-21"}],"filename":"2023RP0083.pdf","filesize":[{"value":"358 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000263/files/2023RP0083.pdf"},"version_id":"91c9119b-6b8a-4bdb-a634-6f2147f23d7a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"医用生体工学","subitem_subject_scheme":"Other"},{"subitem_subject":"神経工学","subitem_subject_scheme":"Other"},{"subitem_subject":"神経補綴","subitem_subject_scheme":"Other"},{"subitem_subject":"人工視覚","subitem_subject_scheme":"Other"},{"subitem_subject":"脳皮質内刺激","subitem_subject_scheme":"Other"},{"subitem_subject":"神経インタフェース","subitem_subject_scheme":"Other"},{"subitem_subject":"電子デバイスシ ステム","subitem_subject_scheme":"Other"},{"subitem_subject":"神経生理学実験","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"超多チャンネル刺激デバイスによる脳皮質内電流場刺激法の開発に向けた定量的実験解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"超多チャンネル刺激デバイスによる脳皮質内電流場刺激法の開発に向けた定量的実験解析","subitem_title_language":"ja"},{"subitem_title":"Quantitative experimental analysis for the development of intracortical current field stimulation using a high-count multi-channel stimulator","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929300332"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-21"},"publish_date":"2023-12-21","publish_status":"0","recid":"2000263","relation_version_is_last":true,"title":["超多チャンネル刺激デバイスによる脳皮質内電流場刺激法の開発に向けた定量的実験解析"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-24T05:36:46.223432+00:00"}