{"created":"2023-12-22T01:41:32.019058+00:00","id":2000273,"links":{},"metadata":{"_buckets":{"deposit":"d12fe901-9d67-4b66-8d10-ac1b4b3d88d1"},"_deposit":{"created_by":15,"id":"2000273","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000273"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000273","sets":["420:724:1701929361491"]},"author_link":[],"control_number":"2000273","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-16","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"抗菌環状ペプチドhypeptinの作用機序解明に用いる化合物供給を目的として、hypeptinの全合成研究を行った。　\nhypeptinのペプチド鎖伸長と環化反応の条件を検討するため、βヒドロキシ基を含まないアミノ酸で構成される構造単純化類縁体を合成した。次に、hypeptinの全合成に用いるβヒドロキシアミノ酸を立体選択的に合成した。合成したβヒドロキシアミノ酸を含む8つのアミノ酸を固相法により伸長し、得られた鎖状ペプチドを液相で環化させた後に、側鎖保護基の除去を試みたが、βヒドロキシ基の保護に用いたベンジル基の除去が困難であることが判明した。","subitem_description_type":"Abstract"},{"subitem_description":"Synthetic study of hypeptin, an antimicrobial cyclic peptide, was conducted toward the elucidation of its action mechanism.\nTo investigate the conditions for peptide chain elongation and cyclization of hypeptin, we synthesized a structurally simplified analogue composed of amino acids without β-hydroxy groups. Next, we synthesized the β-hydroxy amino acids for the total synthesis of hypeptin. The eight amino acids including the synthesized β-hydroxy amino acids were elongated by a solid-phase peptide synthesis. After its cyclization in the solution-phase, the resultant macrocycle was subjected to removal of the protecting groups in the side chains. However, removal of the benzyl group, used for the protection for the β-hydroxy groups, was found to be difficult.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K05841","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"増田, 裕一","creatorNameLang":"ja"},{"creatorName":"MASUDA, Yuichi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-22"}],"filename":"2023RP0093.pdf","filesize":[{"value":"374 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000273/files/2023RP0093.pdf"},"version_id":"9b50ee40-6b0d-48ca-b5a2-c20e5534f9e5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"環状ペプチド","subitem_subject_scheme":"Other"},{"subitem_subject":"抗菌活性","subitem_subject_scheme":"Other"},{"subitem_subject":"全合成","subitem_subject_scheme":"Other"},{"subitem_subject":"βヒドロキシアミノ酸","subitem_subject_scheme":"Other"},{"subitem_subject":"ペプチド合成","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"抗菌環状ペプチドhypeptinの三次元構造および標的分子認識機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗菌環状ペプチドhypeptinの三次元構造および標的分子認識機構の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of 3D structure and target molecule-recognition mechanism of hypeptin, an antimicrobial cyclic peptide.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929361491"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-22"},"publish_date":"2023-12-22","publish_status":"0","recid":"2000273","relation_version_is_last":true,"title":["抗菌環状ペプチドhypeptinの三次元構造および標的分子認識機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-25T02:11:47.324426+00:00"}