{"created":"2023-12-22T02:14:02.928583+00:00","id":2000275,"links":{},"metadata":{"_buckets":{"deposit":"1d56138b-073c-46cb-a9bf-a6561beb0416"},"_deposit":{"created_by":15,"id":"2000275","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000275"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000275","sets":["420:724:1701929361491"]},"author_link":[],"control_number":"2000275","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-18","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"動物細胞の染色体複製ドメイン構造（DNA複製の開始や複製フォークの進行が協調して制御される染色体構造単位）を単一細胞で、かつゲノム網羅的に調べることができる申請者独自の技術 single-cell DNA replication sequencing (scRepli-seq)法を用い、これまでアプローチが困難であった個々の細胞レベルでの染色体構造制御を明らかにした。","subitem_description_type":"Abstract"},{"subitem_description":"We investigated structural characteristics of mammalian chromosomes at the level of individual cells using a novel technique for analyzing replication timing domains (chromosomal unit defined by DNA replication timing). To our surprise, cell-type-specific replication timing domain organization was remarkably conserved between individual cells and even between homologous chromosomes. A small degree of cell-to-cell variation was also detected in specific genomic regions where replication timing shifts during cell differentiation. Thus, our study uncovered the previously unrecognized dynamic and static properties of chromosomal domains.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K06610","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹林, 慎一郎","creatorNameLang":"ja"},{"creatorName":"Takebayashi, Shin-ichiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"平谷, 伊智朗","creatorNameLang":"ja"},{"creatorName":"Hiratani, Ichiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-22"}],"filename":"2023RP0095.pdf","filesize":[{"value":"250 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000275/files/2023RP0095.pdf"},"version_id":"6271d8ef-94c9-46ea-9641-ad26b5d403a6"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"DNA複製","subitem_subject_scheme":"Other"},{"subitem_subject":"染色体","subitem_subject_scheme":"Other"},{"subitem_subject":"シングルセル","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"In vivo単一細胞解析から明らかにする染色体機能ドメインの可塑性とその意義","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"In vivo単一細胞解析から明らかにする染色体機能ドメインの可塑性とその意義","subitem_title_language":"ja"},{"subitem_title":"Stability and flexibility of the DNA replication program revealed by single-cell DNA replication sequencing in vivo","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929361491"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-22"},"publish_date":"2023-12-22","publish_status":"0","recid":"2000275","relation_version_is_last":true,"title":["In vivo単一細胞解析から明らかにする染色体機能ドメインの可塑性とその意義"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-25T02:17:17.064430+00:00"}