{"created":"2023-12-22T06:03:31.729798+00:00","id":2000283,"links":{},"metadata":{"_buckets":{"deposit":"908d399f-cca6-460c-b911-fba64b4d3ed2"},"_deposit":{"created_by":15,"id":"2000283","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000283"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000283","sets":["515:756:1701929619706"]},"author_link":[],"control_number":"2000283","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-05-20","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Ras活性化変異後の発癌プロセスに特化した量的遺伝子座解析動物システムを開発し、発癌物質による肺癌モデルのようにRas変異前のプロセス（発癌物質の代謝、ＤＮＡ修復、体細胞組み換えなどホスト因子による反応など）の影響を最小化した。これにより、これまで見出せなかった肺癌細胞で発現する遺伝子１８個（Srsf6、Cdc7、Chek2、Adam8、Dusp4、Zdhhc2、Naf1、Nat2、Calr、Fto、Ndgr4、Nfat5、Zfhx3、Kmt2a、Sik3、USP32、Mrp23、Trim25）が細胞増殖抑制活性をを、１個（Dek）が細胞増殖促進活性を有する示した。","subitem_description_type":"Abstract"},{"subitem_description":"We have developed an animal system for a quantitative gene locus analysis specialized for the carcinogenic process after Ras activating mutation and hosted the process before Ras mutation (metabolism of carcinogen, DNA repair, somatic cell recombination) like a lung cancer model by a carcinogen. As a result, 18 genes expressed in lung cancer cells that nobody has found so far (Srsf6, Cdc7, Chek2, Adam8, Dusp4, Zdhhc2, Naf1, Nat2, Calr, Fto, Ndgr4, Nfat5, Zfhx3, Kmt2a, Sik3, USP32, Mrp23, Trim25) showed cell proliferation inhibitory activity, and one (Dek) showed cell proliferation promoting activity.","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2021年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K06456","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鈴木, 昇","creatorNameLang":"ja"},{"creatorName":"SUZUKI, NOBORU","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2023-12-22"}],"filename":"2023RP0103.pdf","filesize":[{"value":"82 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000283/files/2023RP0103.pdf"},"version_id":"7d98d0aa-e470-4cc1-8352-ea6fac4f5677"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"発癌モデル動物","subitem_subject_scheme":"Other"},{"subitem_subject":"Rasドライバー発癌","subitem_subject_scheme":"Other"},{"subitem_subject":"発癌制御遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"量的形質遺伝子座解析","subitem_subject_scheme":"Other"},{"subitem_subject":"Quantitative Trait L oci","subitem_subject_scheme":"Other"},{"subitem_subject":"Ras変異","subitem_subject_scheme":"Other"},{"subitem_subject":"ポストRas変異","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"臓器特異的遺伝子編集によるRasドライバー発癌制御遺伝子座解析系の実証的構築","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"臓器特異的遺伝子編集によるRasドライバー発癌制御遺伝子座解析系の実証的構築","subitem_title_language":"ja"},{"subitem_title":"Empirical construction of organ-specific gene editing system for analysing Ras driver carcinogenesis control locus","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1701929619706"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2023-12-22"},"publish_date":"2023-12-22","publish_status":"0","recid":"2000283","relation_version_is_last":true,"title":["臓器特異的遺伝子編集によるRasドライバー発癌制御遺伝子座解析系の実証的構築"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-09-25T04:15:03.275781+00:00"}