{"created":"2024-01-31T01:58:45.484756+00:00","id":2000335,"links":{},"metadata":{"_buckets":{"deposit":"0d735ceb-432e-4166-9018-42e72dfd529a"},"_deposit":{"created_by":16,"id":"2000335","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"2000335"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000335","sets":["334:608:618:1694066935734"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-09-25","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-09-25"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background The current study tested the hypothesis that urinary angiotensinogen (UAGT) and urinary monocyte chemoattractant protein-1 (UMCP-1) levels provide a specifc index of intrarenal renin–angiotensin system (RAS) status and the degree of infltration of macrophages associated with RAS blockade and immunosuppressant treatment in pediatric patients with chronic glomerulonephritis.\nMethods We measured baseline UAGT and UMCP-1 levels to examine the correlation between glomerular injury in 48 pediatric chronic glomerulonephritis patients before treatment. Furthermore, we performed immunohistochemical analysis of angiotensinogen (AGT) and CD68 in 27 pediatric chronic glomerulonephritis patients treated with RAS blockades and immunosuppressants for 2 years. Finally, we examined the efects of angiotensin II (Ang II) on monocyte chemoattractant protein-1 (MCP-1) expression in cultured human mesangial cells (MCs).\nResults Baseline UAGT and UMCP-1 levels positively correlated with urinary protein levels, scores for mesangial hypercellularity, rate of crescentic formation, and expression levels of AGT and CD68 in renal tissues (p<0.05). UAGT and UMCP-1 levels were signifcantly decreased after RAS blockade and immunosuppressant treatment (p<0.01), which was accompanied by AGT and CD68 (p<0.01), as well as the magnitude of glomerular injury. Cultured human MCs showed increased MCP-1 messenger ribonucleic acid and protein levels after Ang II treatment (p<0.01).\nConclusions The data indicates that UAGT and UMCP-1 are useful biomarkers of the degree of glomerular injury during RAS blockade and immunosuppressant treatment in pediatric patients with chronic glomerulonephritis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Department of Pediatrics, Mie University Graduate School of Medicine, Mie, Japan","subitem_description_type":"Other"},{"subitem_description":"9p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第2208号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s00467-023-06026-5","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Pediatric Nephrologyに掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hattori, Tomoki","creatorNameLang":"en"},{"creatorName":"ハットリ, トモキ","creatorNameLang":"ja-Kana"},{"creatorName":"服部, 共樹","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available"}],"displaytype":"detail","filename":"2023DM0916.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2023DM0916","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/2000335/files/2023DM0916.pdf"},"version_id":"13d7640a-b704-44e3-a556-24bd7a0a7300"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Renin–angiotensin system","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Angiotensinogen","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pediatric chronic glomerulonephritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"CD68","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Monocyte chemoattractant protein-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Intrarenal renin-angiotensin system activation and macrophage infiltrations in pediatric chronic glomerulonephritis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Intrarenal renin-angiotensin system activation and macrophage infiltrations in pediatric chronic glomerulonephritis","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["1694066935734"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-06"},"publish_date":"2024-02-06","publish_status":"0","recid":"2000335","relation_version_is_last":true,"title":["Intrarenal renin-angiotensin system activation and macrophage infiltrations in pediatric chronic glomerulonephritis"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-02-06T01:23:07.446968+00:00"}