{"created":"2024-01-31T01:58:52.197065+00:00","id":2000339,"links":{},"metadata":{"_buckets":{"deposit":"cc65f36a-de6f-4389-b340-443aead33d18"},"_deposit":{"created_by":16,"id":"2000339","owners":[16],"pid":{"revision_id":0,"type":"depid","value":"2000339"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000339","sets":["334:608:618:1694066935734"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-09-25","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2023-09-25"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Idiopathic pulmonary fibrosis is a progressive and fatal disease with a poor prognosis.Matrix metalloproteinase-2 is involved in the pathogenesis of organ fibrosis. The role of matrix metalloproteinase-2 in lung fibrosis is unclear. This study evaluated whether overexpression of matrix metalloproteinase-2 affects the development of pulmonary fibrosis. Lung fibrosis was induced by bleomycin in wild-type mice and transgenic mice overexpressing human matrix metalloproteinase2. Mice expressing human matrix metalloproteinase-2 showed significantly decreased infiltration of inflammatory cells and inflammatory and fibrotic cytokines in the lungs compared to wild-type mice after induction of lung injury and fibrosis with bleomycin. The computed tomography score, Ashcroft score of fibrosis, and lung collagen deposition were significantly reduced in human matrix metalloproteinase transgenic mice compared to wild-type mice. The expression of antiapoptotic genes was significantly increased, while caspase-3 activity was significantly reduced in the lungs of matrix metalloproteinase-2 transgenic mice compared to wild-type mice. Active matrix metalloproteinase-2 significantly decreased bleomycin-induced apoptosis in alveolar epithelial cells.Matrix metalloproteinase-2 appears to protect against pulmonary fibrosis by inhibiting apoptosis of lung epithelial cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Department of Immunology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan","subitem_description_type":"Other"},{"subitem_description":"24p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第2212号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.3390/ijms24076695","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"International Journal of Molecular Sciences 2023; 24(7):6695 に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Inoue, Ryo","creatorNameLang":"en"},{"creatorName":"イノウエ, リョウ","creatorNameLang":"ja-Kana"},{"creatorName":"井上, 亮","creatorNameLang":"ja"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available"}],"displaytype":"detail","filename":"2023DM0924.pdf","filesize":[{"value":"56.7 MB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2023DM0924","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/2000339/files/2023DM0924.pdf"},"version_id":"e3dac4e7-4ca2-4b84-a082-197dabd85821"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"matrix metalloproteinases","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pulmonary fibrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"matrix degradation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"apoptosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"collagen deposition","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression","subitem_title_language":"en"}]},"item_type_id":"7","owner":"16","path":["1694066935734"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-02-06"},"publish_date":"2024-02-06","publish_status":"0","recid":"2000339","relation_version_is_last":true,"title":["Amelioration of Pulmonary Fibrosis by Matrix Metalloproteinase-2 Overexpression"],"weko_creator_id":"16","weko_shared_id":-1},"updated":"2024-02-06T01:23:16.995359+00:00"}