{"created":"2024-05-10T05:53:00.712776+00:00","id":2000764,"links":{},"metadata":{"_buckets":{"deposit":"9455aa42-dced-497b-bb8d-fce3d5b42cae"},"_deposit":{"created_by":15,"id":"2000764","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000764"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000764","sets":["334:608:618:1694066935734"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-25","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-25"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A clinical challenge remains in the treatment of hypoxic–ischemic brain injury in newborns. Nicotinamide adenine dinucleotide (NAD+) has beneficial effects in animal models of adult stroke. Here, we aimed to understand the short- and long-term neuroprotective effects of NAD+-promoting substance nicotinamide mononucleotide (NMN) in a well-established brain injury model in neonatal mice. Postnatal day (PND) 9 male and female mice were subjected to cerebral hypoxia–ischemia and treated with saline or NMN (50 mg/kg) immediately after hypoxia–ischemia. At different time points after hypoxia–ischemia, hippocampal NAD+, caspase-3 activity, protein expression of SIRT1, SIRT6, release of high mobility group box-1 (HMGB1), long-term neuropathological outcome, short-term developmental behavior, and long-term motor and memory function were evaluated. Neonatal hypoxia–ischemia reduced NAD+ and SIRT6 levels, but not SIRT1, in the injured hippocampus, while HMGB1 release was significantly increased. NMN treatment normalized hippocampal NAD+ and SIRT6 levels, while caspase-3 activity and HMGB1 release were significantly reduced. NMN alleviated tissue loss in the long-term and improved early developmental behavior, as well as motor and memory function. This study shows that NMN treatment provides neuroprotection in a clinically relevant neonatal animal model of hypoxia ischemia in mice suggesting as a possible novel treatment for neonatal brain injury.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Department of Obstetrics and Gynecology, Mie University, Tsu, Japan","subitem_description_type":"Other"},{"subitem_description":"18p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第2237号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1177/17590914231198983","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"American society for neurochemistry, 2023 Jan-Dec:15に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河村, 卓弥","creatorNameLang":"ja"},{"creatorName":"カワムラ, タクヤ","creatorNameLang":"ja-Kana"},{"creatorName":"Kawamura, Takuya","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-10"}],"filename":"2023DM0310.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","url":{"label":"2023DM0310.pdf","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/2000764/files/2023DM0310.pdf"},"version_id":"18616175-6c67-4627-b92c-1474ad61aafb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"sirtuins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alarmins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"infant","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hypoxic–ischemic encephalopathy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nicotinamide adenine dinucleotide","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic-Ischemic Brain Injury in Neonatal Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic-Ischemic Brain Injury in Neonatal Mice","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1694066935734"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-10"},"publish_date":"2024-05-10","publish_status":"0","recid":"2000764","relation_version_is_last":true,"title":["Therapeutic Effect of Nicotinamide Mononucleotide for Hypoxic-Ischemic Brain Injury in Neonatal Mice"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-05-10T06:04:24.020518+00:00"}