{"created":"2024-05-13T02:12:18.469809+00:00","id":2000772,"links":{},"metadata":{"_buckets":{"deposit":"ce93ab35-5650-4023-86ff-fb4e1717e86a"},"_deposit":{"created_by":15,"id":"2000772","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000772"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000772","sets":["334:608:618:1694066935734"]},"author_link":[],"item_7_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-25","bibliographicIssueDateType":"Issued"}}]},"item_7_date_granted_59":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2024-03-25"}]},"item_7_degree_grantor_57":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_name":"三重大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"14101","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_7_degree_name_56":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士(医学)"}]},"item_7_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_7_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Matricellular proteins have been implicated in pathologies after subarachnoid hemorrhage (SAH). To find a new therapeutic molecular target, the present study aimed to clarify the relationships between serially measured plasma levels of a matricellular protein, secreted protein acidic and rich in cysteine (SPARC), and delayed cerebral ischemia (DCI) in 117 consecutive aneurysmal SAH patients with admission World Federation of Neurological Surgeons (WFNS) grades I–III. DCI developed in 25 patients with higher incidences of past history of hypertension and dyslipidemia, preoperative WFNS grade III, modified Fisher grade 4, spinal drainage, and angiographic vasospasm. Plasma SPARC levels were increased after SAH, and significantly higher in patients with than without DCI at days 7–9, and in patients with VASOGRADE-Yellow compared with VASOGRADE-Green at days 1–3 and 7–9. However, there were no relationships between plasma SPARC levels and angiographic vasospasm. Receiver-operating characteristic curves differentiating DCI from no DCI determined the cut-off value of plasma SPARC ≥ 82.1 ng/ml at days 7-9 (sensitivity, 0.800; specificity, 0.533; and area under the curve, 0.708), which was found to be an independent determinant of DCI development in multivariate analyses. This is the first study to show that SPARC is upregulated in peripheral blood after SAH, and that SPARC may be involved in the development of DCI without angiographic vasospasm in a clinical setting.","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文/Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Japan","subitem_description_type":"Other"},{"subitem_description":"15p","subitem_description_type":"Other"}]},"item_7_dissertation_number_60":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲医学第2245号"}]},"item_7_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_7_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s13311-023-01351-x","subitem_relation_type_select":"DOI"}}]},"item_7_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_7_text_63":{"attribute_name":"ノート","attribute_value_mlt":[{"subitem_text_value":"Neurotherapeutics 2023;20(3) :779-788に掲載"}]},"item_7_text_65":{"attribute_name":"資源タイプ（三重大）","attribute_value_mlt":[{"subitem_text_value":"Doctoral Dissertation / 博士論文"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中島, 英貴","creatorNameLang":"ja"},{"creatorName":"ナカジマ, ヒデキ","creatorNameLang":"ja-Kana"},{"creatorName":"Nakajima, Hideki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-05-13"}],"filename":"2023DM0326.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","url":{"label":"2023DM0326.pdf","objectType":"fulltext","url":"https://mie-u.repo.nii.ac.jp/record/2000772/files/2023DM0326.pdf"},"version_id":"9f8af0cb-d6af-42e6-a237-4c59dc20167d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Delayed cerebral ischemia","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Early brain injury","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Matricellular protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"SPARC","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Subarachnoid hemorrhage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"VASOGRADE","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"doctoral thesis","resourceuri":"http://purl.org/coar/resource_type/c_db06"}]},"item_title":"Plasma SPARC Elevation in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Plasma SPARC Elevation in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage","subitem_title_language":"en"}]},"item_type_id":"7","owner":"15","path":["1694066935734"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-05-13"},"publish_date":"2024-05-13","publish_status":"0","recid":"2000772","relation_version_is_last":true,"title":["Plasma SPARC Elevation in Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-05-13T02:24:15.898079+00:00"}