{"created":"2024-10-17T00:26:04.489293+00:00","id":2000930,"links":{},"metadata":{"_buckets":{"deposit":"abf3ff0e-74fc-4b98-8d6d-7a0b926c749f"},"_deposit":{"created_by":15,"id":"2000930","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000930"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000930","sets":["334:627:1728958044917"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-22","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"一次線毛（primary cilia）は、中心体が形態的・機能的に変化した細胞小器官である。一次線毛の形成不全や機能異常は、線毛病と呼ばれる種々の疾患や発生異常の原因となるが病態生理には不明な点が多く残されている。本研究では、一次線毛の制御因子であるトリコプレインのノックアウトマウスを作製・解析した結果、肥満及び骨格筋再生において一次線毛が重要な役割を担うこと、その分子機序を明らかにした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Primary cilia play pivotal roles in signal transduction and development, and are known to serve as signaling hubs. In this study, we show that genetic ablation of trichoplein (Tchp) induces ciliary elongation on adipose progenitors (APs) in skin and fibro-adipogenic progenitors (FAPs) in injured skeletal muscle. The elongated cilia on APs suppress adipogenic differentiation by disrupting cilia-dependent lipid raft dynamics, which protects mice from high fat diet-induced obesity. Furthermore, the elongated cilia on FAPs accelerate interleukin 13 secretion from FAPs, which promotes skeletal muscle regeneration. further of APs and promote regeneration of muscle fibers. Overall, our results suggest a novel role for primary cilia in regulating adipogenesis and skeletal muscle regeneration.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(基盤研究(B))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20H03448","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"笠原, 広介","creatorNameLang":"ja"},{"creatorName":"Kasahara, Kousuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"白水, 崇","creatorNameLang":"ja"},{"creatorName":"Shiromizu, Takashi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"山川, 大史","creatorNameLang":"ja"},{"creatorName":"Yamakawa, Daishi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-17"}],"filename":"2024RP0021.pdf","filesize":[{"value":"83 KB"}],"format":"application/pdf","url":{"label":"2024RP0021.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000930/files/2024RP0021.pdf"},"version_id":"a6a4d8e4-f8f7-4bd5-b783-6ed9b6955260"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"一次線毛","subitem_subject_scheme":"Other"},{"subitem_subject":"肥満","subitem_subject_scheme":"Other"},{"subitem_subject":"骨格筋再生","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ユビキチンシグナルによる一次線毛の形成機構と癌細胞増殖制御への標的化戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ユビキチンシグナルによる一次線毛の形成機構と癌細胞増殖制御への標的化戦略","subitem_title_language":"ja"},{"subitem_title":"Regulation of primary cilia formation by the ubiquitinーproteasome system","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-17"},"publish_date":"2024-10-17","publish_status":"0","recid":"2000930","relation_version_is_last":true,"title":["ユビキチンシグナルによる一次線毛の形成機構と癌細胞増殖制御への標的化戦略"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-17T00:35:22.121966+00:00"}