{"created":"2024-10-17T01:51:09.831833+00:00","id":2000933,"links":{},"metadata":{"_buckets":{"deposit":"5352ecec-e277-4c1f-bd7c-38836f253297"},"_deposit":{"created_by":15,"id":"2000933","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000933"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000933","sets":["334:627:1728958044917"]},"author_link":[],"control_number":"2000933","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-06-11","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"大型実験動物を用いて、化学療法群にはドキソルビシン(1.5-2.0 mg/kg)を3週毎に計4回静脈内投与を行い、治療前、アンスラサイクリン１回投与後、2回投与後、3回投与後、4回投与後の計5回にわたり心臓MRI撮像を施行した。未発症群と比較すると、薬剤性心筋症発症群では第６週および９週目で心筋組織性状指標の上昇を認め、第１２週目では統計学的な有意差を認めた。しかし、個体間での信号強度のばらつき、経時測定データの重なりを認め、反復測定分散分析では両群間の経時的変化に差異は認められなかった。これらのバイオマーカーを臨床応用するためには、より精度の高い評価法が必要であると考えられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Large animal models (swine) underwent serial CMR scans, including cine, tissue characterization via T1 and T2 mapping, late gadolinium enhancement, and same-day doxorubicin injection (1.5-2.0mg/kg, 4-cycle) every 3 weeks. Three age/weight-matched (to latest scan) swine served as the control. After 12 weeks, explanted hearts were used for assessing the frequency of doxorubicin-induced cardiac lesions. Native T1, extracellular volume (ECV), and T2 at 12 weeks were significantly higher in swine with cardiotoxicity than those without cardiotoxicity. The temporal trends in native T1, ECV, and T2 in swine with cardiotoxicity showed similar and statistically significant increases, while there were no differences in their temporal changes between the two groups. Serial CMR imaging alone has a limited ability to detect histologic cardiotoxicity.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2022年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K08579","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中森, 史朗","creatorNameLang":"ja"},{"creatorName":"Nakamori, Shiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"伊藤, 正明","creatorNameLang":"ja"},{"creatorName":"Ito, Masaaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"土肥, 薫","creatorNameLang":"ja"},{"creatorName":"Dohi, Kaoru","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"佐久間, 肇","creatorNameLang":"ja"},{"creatorName":"Sakuma, Hajime","creatorNameLang":"en"}]},{"creatorAlternatives":[{"creatorAlternative":"今中, 恭子","creatorAlternativeLang":"ja"}],"creatorNames":[{"creatorName":"吉田, 恭子","creatorNameLang":"ja"},{"creatorName":"Imanaka-Yoshida Kyoko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"水野, 聡朗","creatorNameLang":"ja"},{"creatorName":"Mizuno, Toshiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"藤本, 直紀","creatorNameLang":"ja"},{"creatorName":"Fujimoto, Naoki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"小川, 朋子","creatorNameLang":"ja"},{"creatorName":"Ogawa, Tomoko","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-17"}],"filename":"2024RP0024.pdf","filesize":[{"value":"956 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2024RP0024.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000933/files/2024RP0024.pdf"},"version_id":"8651342f-6612-4fac-bea1-d5c3589e5bc9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"薬剤性心筋障害","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋組織性状","subitem_subject_scheme":"Other"},{"subitem_subject":"早期診断","subitem_subject_scheme":"Other"},{"subitem_subject":"画像診断","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"薬剤性心筋症早期診断を目指した非侵襲的心筋組織性状評価法の有用性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"薬剤性心筋症早期診断を目指した非侵襲的心筋組織性状評価法の有用性の検討","subitem_title_language":"ja"},{"subitem_title":"Noninvasive biomarkers for early detection of chemotherapy-related cardiac dysfunction","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-17"},"publish_date":"2024-10-17","publish_status":"0","recid":"2000933","relation_version_is_last":true,"title":["薬剤性心筋症早期診断を目指した非侵襲的心筋組織性状評価法の有用性の検討"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-17T02:08:41.748506+00:00"}