{"created":"2024-10-17T04:15:49.887071+00:00","id":2000935,"links":{},"metadata":{"_buckets":{"deposit":"04ab66a2-6cf9-48a2-b3b1-628be223ebed"},"_deposit":{"created_by":15,"id":"2000935","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000935"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000935","sets":["334:627:1728958044917"]},"author_link":[],"control_number":"2000935","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-17","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"筋特異的中間径フィラメントタンパク質であるデスミンのリン酸化不全マウスは、野生型マウスと比べ、骨格筋障害後の筋再生が遅延する。本研究では、障害初期の筋組織解析から、デスミンリン酸化不全マウスでは、有意に筋線維サイズが小さく、細胞核数も少なかったため、筋芽細胞の増殖あるいは融合の遅延が考えられた。マウス筋肉からの筋芽細胞の初代培養を行い、上記仮説を検討したが、増殖や融合には変化は見られなかった。一方で、デスミンリン酸化不全マウス由来筋芽細胞では、デスミンタンパク質の凝集が観察され、フィラメントとしての安定性の消失が判明した。さらに血液解析では、血中トリグリセリド値の上昇が確認できた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"A muscle-specific intermediate filament protein, desmin phosphorylation-deficient mice have delayed muscle regeneration after skeletal muscle injury compared with wild-type mice. In this study, muscle tissue analysis at the early stage of injury revealed that desmin phosphorylation-deficient mice had significantly smaller muscle fiber sizes and fewer cell nuclei, suggesting delays in myoblast proliferation or fusion. Primary cultures of myoblasts from mouse muscle were performed to test the above hypothesis, but no change in proliferation or fusion was observed. On the other hand, desmin protein aggregation was observed in mouse-derived myoblasts derived from desmin phosphorylation-deficient mice, indicating a loss of filament stability. Furthermore, blood analysis confirmed an increase in serum triglyceride levels.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K07356","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山川, 大史","creatorNameLang":"ja"},{"creatorName":"Yamakawa, Daishi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"稲垣, 昌樹","creatorNameLang":"ja"},{"creatorName":"Inagaki, Masaki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-17"}],"filename":"2024RP0026.pdf","filesize":[{"value":"251 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000935/files/2024RP0026.pdf"},"version_id":"fc214a3e-0e2c-4e89-b962-da13e51df2a3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"中間径フィラメント","subitem_subject_scheme":"Other"},{"subitem_subject":"骨格筋","subitem_subject_scheme":"Other"},{"subitem_subject":"デスミン","subitem_subject_scheme":"Other"},{"subitem_subject":"リン酸化","subitem_subject_scheme":"Other"},{"subitem_subject":"筋再生","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"筋肉障害及び修復におけるデスミンリン酸化の生理的・病態的意義の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"筋肉障害及び修復におけるデスミンリン酸化の生理的・病態的意義の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the physiological and pathological significance of desmin phosphorylation in muscle damage and repair","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-17"},"publish_date":"2024-10-17","publish_status":"0","recid":"2000935","relation_version_is_last":true,"title":["筋肉障害及び修復におけるデスミンリン酸化の生理的・病態的意義の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-17T04:29:13.918344+00:00"}