{"created":"2024-10-17T04:37:27.990599+00:00","id":2000936,"links":{},"metadata":{"_buckets":{"deposit":"91118dcd-4efa-42a7-b90d-da305bd92ab1"},"_deposit":{"created_by":15,"id":"2000936","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000936"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000936","sets":["334:627:1728958044917"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-06-09","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"転写因子AP2-Gの標的遺伝子及びcis配列を同定した。その標的遺伝子中に新規雌ガメトサイトの転写因子AP2-FG2を見出した。AP2-FG2は雌ガメトサイトの核に局在し雌特異的遺伝子の上流域へ結合しその遺伝子発現を制御する事を明らかにした。さらに雄ガメトサイトの分化に関与するSNF2-like chromatin remodeling ATPase、gSNF2を見出した。gSNF2欠損原虫では正常な雄ガメトサイトを形成することができず蚊への伝播能が完全に失われていた。gSNF2は雌雄ガメトサイト遺伝子群の上流域に存在する特異的配列に結合し、その遺伝子発現制御に関与する事を明らかにした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"The target gene and cis-acting element of the transcription factor AP2-G were identified. We found a novel female gametocyte transcription factor AP2-FG2 in the target gene. We found that AP2-FG2 is localized in the nucleus of female gametocytes and binds to the upstream regions of female-specific genes to regulate their gene expression. Furthermore, we found an SNF2-like chromatin remodeling ATPase, gSNF2, which is involved in the differentiation of male gametocytes. The gSNF2-deficient parasites were unable to form normal male gametocytes and completely lost the ability to infection to mosquitoes. We clarified that gSNF2 binds to a specific sequence existing in the upstream region of the male and female gametocyte genes and participates in the gene expression regulation.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度~2022年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K07462","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者(ヨミ)","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金子, 伊澄","creatorNameLang":"ja"},{"creatorName":"Kaneko, Izumi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-17"}],"filename":"2024RP0027.pdf","filesize":[{"value":"725 KB"}],"format":"application/pdf","url":{"label":"2024RP0027.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000936/files/2024RP0027.pdf"},"version_id":"ac4be8bd-3c7d-42b6-8956-bd466e3fb198"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マラリア","subitem_subject_scheme":"Other"},{"subitem_subject":"転写因子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"転写因子を手掛かりとしたマラリア原虫ガメトサイト形成機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"転写因子を手掛かりとしたマラリア原虫ガメトサイト形成機構の解明","subitem_title_language":"ja"},{"subitem_title":"Mechanisms of triggering malaria gametocytogenesis by AP2-G.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-17"},"publish_date":"2024-10-17","publish_status":"0","recid":"2000936","relation_version_is_last":true,"title":["転写因子を手掛かりとしたマラリア原虫ガメトサイト形成機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-17T05:17:45.488358+00:00"}