{"created":"2024-10-17T05:45:13.230877+00:00","id":2000938,"links":{},"metadata":{"_buckets":{"deposit":"8403c5d7-9843-4182-8a33-907fb72e0dc5"},"_deposit":{"created_by":15,"id":"2000938","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000938"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000938","sets":["334:627:1728958044917"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-08","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"乳幼児突然死症候群（SIDS）は、これまで元気にしていた児が睡眠中に突然無呼吸に陥り、覚醒できずに亡くなる疾患で、その発症機序は不明である。私は、SIDSで亡くなった児の脳幹のセロトニン神経系に異常が見られたこと、SIDSで亡くなる前、児の85％以上に軽度の感染症状があったことを動物モデルで再現することで、SIDSモデルラットを作成した。私が作成したSIDSモデルラットは、疑似細菌感染２４時間後の死亡率の増加が見られ、橋・延髄の遺伝子発現にも異常がある。また、リアルタイムPCRにより解析した結果、SIDSモデルラットの橋・延髄で7つのケモカインの発現量が増加していることを明らかにした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Sudden infant death syndrome (SIDS) is the sudden death during sleep of seemingly healthy infant which remains unexpected after a thorough investigation. I developed SIDS model rat based on results of epidemiological studies. My SIDS model rat at postnatal day (P) 11 showed increasement of death rate after 24 hours of lipopolysaccharide (LPS) administration. In addition, SIDS model rat at P11 showed abnormalities of gene expression in pons and medulla after 4 hours of LPS administration. Moreover, I revealed that expression levels of seven cytokines are increased in SIDS model rat pons and medulla at P11 after 4 hours of LPS administration.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K08179","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大河原, 剛","creatorNameLang":"ja"},{"creatorName":"Ohkawara, Takeshi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-17"}],"filename":"2024RP0029.pdf","filesize":[{"value":"228 KB"}],"format":"application/pdf","url":{"label":"2024RP0029.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000938/files/2024RP0029.pdf"},"version_id":"e06f3471-cce0-47f3-9773-c9f9d7796d09"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"乳幼児突然死症候群","subitem_subject_scheme":"Other"},{"subitem_subject":"ケモカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"セロトニン神経系","subitem_subject_scheme":"Other"},{"subitem_subject":"胎生期のウイルス感染","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"乳幼児突然死症候群モデル動物の開発と解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"乳幼児突然死症候群モデル動物の開発と解析","subitem_title_language":"ja"},{"subitem_title":"The development and analysis of sudden infant death syndrom (SIDS) model animal","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-17"},"publish_date":"2024-10-17","publish_status":"0","recid":"2000938","relation_version_is_last":true,"title":["乳幼児突然死症候群モデル動物の開発と解析"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-17T06:04:20.636836+00:00"}