{"created":"2024-10-17T23:40:01.152704+00:00","id":2000939,"links":{},"metadata":{"_buckets":{"deposit":"9bb74e28-c1b1-42f7-b680-0b4a1c39c2c5"},"_deposit":{"created_by":15,"id":"2000939","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000939"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000939","sets":["334:627:1728958044917"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-19","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"自閉症は、コミュニケーション障害・社会性の障害・常同行動といった中核症状のほかに、感覚過敏など感覚処理の問題がしばしば合併する。本研究では、ヒト自閉症における嗅覚過敏の病態解明と自閉症児のQOL向上を目指し、自閉症モデルラットを用いて嗅覚刺激に対する嗅覚神経系の生理学的・形態学的解析を行った。\n新生仔ラットにおける嗅覚系行動実験（Nest-seeking test）を行い、自閉症モデルラットでは嗅覚に対する感受性が高いことが示された。成獣ラットでは４種類の匂い物質のうち、1,8-シネオールに対して自閉症モデルラットの後梨状皮質におけるc-fos陽性細胞の増加が認められた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Autism spectrum disorders (ASD) is characterized by impairment in social interaction; communication abnormalities; and limited activity and curiosity. Sensory hypersensitivity is frequently observed with ASD. In this study, I performed behavioral and morphological analysis of the olfactory nervous system in response to olfactory stimuli using autism model rats.\nBehavioral experiments on the olfactory system in neonatal rats (Nest-seeking test) showed that the autism model rats tended to be highly sensitive to the smell of home cage. Adult rats were exposed to four odorants. Increased c-fos positive cells in the posterior piriform cortex of autism model rats were observed for 1,8-cineole.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K08205","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAlternatives":[{"creatorAlternative":"伊田, みちる","creatorAlternativeLang":"ja"}],"creatorNames":[{"creatorName":"江藤, みちる","creatorNameLang":"ja"},{"creatorName":"Ida-Eto, Michiru","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-17"}],"filename":"2024RP0030.pdf","filesize":[{"value":"79 KB"}],"format":"application/pdf","url":{"label":"2024RP0030.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000939/files/2024RP0030.pdf"},"version_id":"6128628a-3d52-4117-b195-1259b5fbd668"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"自閉症","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"サリドマイド","subitem_subject_scheme":"Other"},{"subitem_subject":"嗅覚","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"自閉症モデルラットを用いた自閉症児における嗅覚過敏の機序解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自閉症モデルラットを用いた自閉症児における嗅覚過敏の機序解明","subitem_title_language":"ja"},{"subitem_title":"Mechanism of olfactory hypersensitivity in human autism using autism model rats","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-17"},"publish_date":"2024-10-17","publish_status":"0","recid":"2000939","relation_version_is_last":true,"title":["自閉症モデルラットを用いた自閉症児における嗅覚過敏の機序解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-17T23:48:04.487585+00:00"}