{"created":"2024-10-18T01:09:24.155731+00:00","id":2000944,"links":{},"metadata":{"_buckets":{"deposit":"2ab11dac-178e-4dad-96e6-d3b53ba32c0a"},"_deposit":{"created_by":15,"id":"2000944","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000944"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000944","sets":["334:627:1728958044917"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-30","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"m6a-RNAメチル化制御遺伝子発現のうちFTO-mRNA高発現は複数の臨床病理学的因子の悪性度と相関し、FTO-mRNA高発現群は低発現群と比べて有意に生存/再発予後不良であった。FTO-shRNAを用いたFTO-stable knockdownの効率は非常に良くSh-FTO群では、胃癌細胞の増殖能/浸潤能が顕著に低下していた。マウス実験でもFTO stable knockdownをおこなったxenograft tumorの増殖は著明に抑制されていた。またFTO stable knockdownによってEMT関連遺伝子のvimentinが著明減少していた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Patients with high FTO expression exhibited markedly worse OS. Then we observed that FTO expression was frequently upregulated in GC cell lines, with epithelial-mesenchymal-transition (EMT) features. FTO knockdown in HGC27 and AGS cells inhibited cell proliferation and migratory potential, while its overexpression in MKN28 cells resulted in enhanced proliferation and migration. Finally, confirming our in-vitro findings, FTO suppression led to significant tumor growth inhibition in a HGC27 xenograft model.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K09004","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 光司","creatorNameLang":"ja"},{"creatorName":"Tanaka, Koji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"問山, 裕二","creatorNameLang":"ja"},{"creatorName":"Toiyama, Yuji","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"奥川, 喜永","creatorNameLang":"ja"},{"creatorName":"Okugawa, Yoshinaga","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"大井, 正貴","creatorNameLang":"ja"},{"creatorName":"Ohi, Masaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"楠, 正人","creatorNameLang":"ja"},{"creatorName":"Kusunoki, Masato","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-18"}],"filename":"2024RP0035.pdf","filesize":[{"value":"176 KB"}],"format":"application/pdf","url":{"label":"2024RP0035.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000944/files/2024RP0035.pdf"},"version_id":"40b7016a-87a9-4096-8526-7400563335c2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胃癌","subitem_subject_scheme":"Other"},{"subitem_subject":"RNAメチル化","subitem_subject_scheme":"Other"},{"subitem_subject":"FTO","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"RNAメチル化を介した胃癌腹膜播種進展の機序解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"RNAメチル化を介した胃癌腹膜播種進展の機序解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation for mchanism of pritoneal metastasis via RNA methylation in gastric cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-18"},"publish_date":"2024-10-18","publish_status":"0","recid":"2000944","relation_version_is_last":true,"title":["RNAメチル化を介した胃癌腹膜播種進展の機序解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-18T01:19:17.430203+00:00"}