{"created":"2024-10-18T05:25:54.388466+00:00","id":2000950,"links":{},"metadata":{"_buckets":{"deposit":"732f000a-54f1-4ca0-96c7-e70fe6298250"},"_deposit":{"created_by":15,"id":"2000950","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000950"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000950","sets":["334:627:1728958044917"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-26","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"生体肝移植において術後グラフト肝機能不全の原因として血栓性微小血管障害症が注目されている。マウス虚血再還流モデルにおいて、von Willebrand Factorを分解するADAMTS13を投与することにより肝機能改善効果を評価した。しかし有意な効果はみられず、同じく抗凝固因子であるエドキサバン投与による効果を検討した。結果、術後肝障害が軽減された。その作用機序として、抗凝固作用による肝組織の類洞鬱血の改善を認めるのみならず、炎症性サイトカインの抑制や肝組織への炎症細胞浸潤の抑制効果も見られた。さらにアポトーシス抑制効果も見られ、それらが総合的に作用し、肝障害を抑制しているものと考えられた。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Thrombotic microangiopathy is one of the cause of graft failure after living donor liver transplantation. In mice liver ischemia-reperfusion injury (IRI) model, we evaluated the efficacy of ADAMTS13, which was a cleavage enzyme of von Willebrand Factor, in liver IRI. However, there was no significant efficacy. Therefore, we administered FXa inhibitor, edoxaban, as anticoagulant agent.\nPostoperative liver injury was alleviated. As anticoagulant effect, sinusoidal congestion was improved in the live tissue. Moreover, inflammatory cytokines and chemokines were reduced, and the infiltration of inflammatory cells into liver tissue was attenuated. Apoptosis of hepatocyte was also prevented. FXa protected liver IRI by these anticoagulant, anti inflammatory and anti-apoptotic effects.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2022年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K18111","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"種村, 彰洋","creatorNameLang":"ja"},{"creatorName":"Tanemura, Akihiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-18"}],"filename":"2024RP0041.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","url":{"label":"2024RP0041.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000950/files/2024RP0041.pdf"},"version_id":"be5403f1-303a-4ff9-a251-54a1baa6b435"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"血栓性微小血管障害","subitem_subject_scheme":"Other"},{"subitem_subject":"生体肝移植","subitem_subject_scheme":"Other"},{"subitem_subject":"肝虚血再還流障害","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"生体肝移植術後の血栓性微小血管障害症の病態解明とグラフト肝機能の改善を目指して","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"生体肝移植術後の血栓性微小血管障害症の病態解明とグラフト肝機能の改善を目指して","subitem_title_language":"ja"},{"subitem_title":"Analysis to elucidate the pathogenesis of thrombotic microangiopathy and improve graft function after living donor liver transplantation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-18"},"publish_date":"2024-10-18","publish_status":"0","recid":"2000950","relation_version_is_last":true,"title":["生体肝移植術後の血栓性微小血管障害症の病態解明とグラフト肝機能の改善を目指して"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-18T05:37:52.707004+00:00"}