{"created":"2024-10-22T00:51:38.473839+00:00","id":2000953,"links":{},"metadata":{"_buckets":{"deposit":"c174fed7-09d4-4aaa-9ce0-afac18cf744b"},"_deposit":{"created_by":15,"id":"2000953","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000953"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000953","sets":["334:627:1728958044917"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-06-10","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"リンパ管内皮細胞は静脈内皮細胞からの出芽による単一起源に由来すると考えられてきた。申請者らは、心臓リンパ管の独自起源や発生を制御するシグナルが存在する事を報告した(Maruyama et al., Dev bio, 2019, iScience, 2021)。つまり、心臓構成細胞である転写因子Islet1を発現する未分化中胚葉細胞の分化により心臓リンパ管の50-60%が形成される。さらに、申請者が同定した心臓リンパ管起源が、頭頸部筋肉・心筋の起源として近年同定された心臓咽頭中胚葉 (CPM)であるという事を明らかにした (Maruyama et al. , eLife. 2022)。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Lymphatic endothelial cells were once believed to originate solely through sprouting from venous endothelial cells . However, recent research has revealed that 50-60% of cardiac lymphatic vessels actually form through the differentiation of undifferentiated mesoderm cells(Dev Biol, 2019; iScience, 2021). These cells express the transcription factor Islet1, a key component of cardiac development. The origin of these cardiac lymphatic vessels has now been identified as the cardiac pharyngeal mesoderm (CPM). This region was later distinguished as the source of head and neck muscles as well as myocardium (Maruyama et al., eLife, 2022).","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K17072","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"丸山, 和晃","creatorNameLang":"ja"},{"creatorName":"Maruyama, Kazuaki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-22"}],"filename":"2024RP0044.pdf","filesize":[{"value":"85 KB"}],"format":"application/pdf","url":{"label":"2024RP0044.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000953/files/2024RP0044.pdf"},"version_id":"596b9b8d-b518-494d-b9ab-761d556bf64a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"リンパ管","subitem_subject_scheme":"Other"},{"subitem_subject":"血管","subitem_subject_scheme":"Other"},{"subitem_subject":"心臓","subitem_subject_scheme":"Other"},{"subitem_subject":"発生学","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"心臓・血管病理","subitem_subject_scheme":"Other"},{"subitem_subject":"疾患モデル","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"臓器特異的リンパ管発生機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"臓器特異的リンパ管発生機構の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidating the organ-specific lymphatic vessel development","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-22"},"publish_date":"2024-10-22","publish_status":"0","recid":"2000953","relation_version_is_last":true,"title":["臓器特異的リンパ管発生機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-22T01:04:44.448338+00:00"}