{"created":"2024-10-22T01:17:19.652945+00:00","id":2000954,"links":{},"metadata":{"_buckets":{"deposit":"c7da4d6a-3050-4f4a-a44c-019883808060"},"_deposit":{"created_by":15,"id":"2000954","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000954"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000954","sets":["334:627:1728958044917"]},"author_link":[],"control_number":"2000954","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-17","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、C14の炭素鎖を有する塩化ベンザルコニウム(BAC)がC12の炭素鎖を有するBACと比較して低濃度で毒性を発現すると仮説を立て、BACの体内動態と臓器傷害性を炭素鎖間で比較検証した。その結果、BACの体内動態や臓器傷害性は炭素鎖間で同等であり、本研究の手法では仮説通りの結果を得ることができなかった。一方、研究遂行の過程において、プログラムされた細胞死の一種であるアポトーシスを伴う急性肺傷害をBAC経口摂取後の新たな中毒機序として見出した。これらの成果は、BAC中毒死の法医学的診断基準の確立のための基礎的情報になると考えられる。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we hypothesized that benzalkonium chloride (BAC) with a carbon chains C14 would be toxic at lower concentrations than BAC with a carbon chains C12. We compared the pharmacokinetics and organ toxicity of BAC between carbon chains using mice. The pharmacokinetics and organ toxicity of BAC were similar between carbon chains, and it could not obtain results that conform to the hypothesis in the method of this study. On the other hand, we discovered acute lung injury with apoptosis as a novel toxic mechanism after oral BAC ingestion in the courses of the study. These findings will be useful as a basic information for establishment of forensic diagnostic criteria for BAC poisoning.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K18980","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関島, 秀久","creatorNameLang":"ja"},{"creatorName":"Sekijima, Hidehisa","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-22"}],"filename":"2024RP0045.pdf","filesize":[{"value":"375 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2024RP0045.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000954/files/2024RP0045.pdf"},"version_id":"dc025522-b78f-4762-9eab-755efca5f439"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"塩化ベンザルコニウム","subitem_subject_scheme":"Other"},{"subitem_subject":"炭素鎖長","subitem_subject_scheme":"Other"},{"subitem_subject":"致死量","subitem_subject_scheme":"Other"},{"subitem_subject":"体内動態","subitem_subject_scheme":"Other"},{"subitem_subject":"臓器傷害","subitem_subject_scheme":"Other"},{"subitem_subject":"急性肺傷害","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞死","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"法医学的診断基準の確立に向けた炭素鎖長の異なる塩化ベンザルコニウムの毒性機序解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"法医学的診断基準の確立に向けた炭素鎖長の異なる塩化ベンザルコニウムの毒性機序解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the toxic mechanism of benzalkonium chloride differing in carbon chain length for establishment of diagnostic criteria in forensic medicine","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-22"},"publish_date":"2024-10-22","publish_status":"0","recid":"2000954","relation_version_is_last":true,"title":["法医学的診断基準の確立に向けた炭素鎖長の異なる塩化ベンザルコニウムの毒性機序解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-27T23:44:18.415110+00:00"}