{"created":"2024-10-22T04:40:33.464761+00:00","id":2000960,"links":{},"metadata":{"_buckets":{"deposit":"8dcd165a-9294-45df-82cc-4d8befebe1d3"},"_deposit":{"created_by":15,"id":"2000960","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000960"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000960","sets":["334:627:1728958044917"]},"author_link":[],"control_number":"2000960","item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-20","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"2型自然リンパ球(ILC2)は、癌の種類や微小環境に影響されて腫瘍抑制および腫瘍促進の相反する二つの作用を有することが知られている。我々は乳癌肺転移モデルマウスを用いて、乳癌肺転移におけるILC2が果たす役割を検討した。micro-metastasis、macro-metastasisにおけるILC2の数や頻度に変化はなかったが、macro-metastasisにおいてはILC2の細胞表面マーカーやサイトカイン産生能が活性化していた。更に、ILC2から産生されるIL-13を介して骨髄由来免疫抑制細胞が活性化され、転移カスケードを通して腫瘍増殖を許容する微小環境を構築している可能性が示唆された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"When breast cancer metastasizes to the lung, group 2 innate lymphoid cells (ILC2s) are thought to promote tumor growth via the activation of myeloid-derived suppressor cells (MDSCs). In this study, we aimed to characterize the dynamic interactions of ILC2s and MDSCs during the course of cancer progression from the micrometastatic to the macrometastatic stages. We found that ILC2s were activated in both the micro- and macrometastatic regions, suggesting sustained activation throughout the metastatic cascades. In addition, our findings indicate that ILC2s may induce the immunosuppressive functions of MDSCs during the later stages of metastasis.Concomitantly, ILC2 may instigate extracellular matrix remodeling by polymorphonuclear (PMN)-MDSC activation during the early stages of metastasis.\nThese metastatic-stage-specific changes may contribute to metastatic tumor growth in the microenvironment of breast cancer lung metastasis.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2019年度～2022年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"19K18210","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 温志","creatorNameLang":"ja"},{"creatorName":"Ito, Atsushi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-22"}],"filename":"2024RP0051.pdf","filesize":[{"value":"320 KB"}],"format":"application/pdf","mimetype":"application/pdf","url":{"label":"2024RP0051.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000960/files/2024RP0051.pdf"},"version_id":"e18f2549-9853-433d-a37e-ca3b779481c5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"2型自然リンパ球","subitem_subject_scheme":"Other"},{"subitem_subject":"がん","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍微小環境","subitem_subject_scheme":"Other"},{"subitem_subject":"骨髄由来免疫抑制細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"間質性肺炎合併肺癌で2型自然リンパ球が果たす2つの役割：線維化促進と腫瘍免疫抑制","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"間質性肺炎合併肺癌で2型自然リンパ球が果たす2つの役割：線維化促進と腫瘍免疫抑制","subitem_title_language":"ja"},{"subitem_title":"Role of group 2 innate lymphoid cells in the lung cancer microenvironment","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-22"},"publish_date":"2024-10-22","publish_status":"0","recid":"2000960","relation_version_is_last":true,"title":["間質性肺炎合併肺癌で2型自然リンパ球が果たす2つの役割：線維化促進と腫瘍免疫抑制"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-22T04:53:02.686711+00:00"}