{"created":"2024-10-22T04:56:26.451487+00:00","id":2000961,"links":{},"metadata":{"_buckets":{"deposit":"cd7e61e9-e890-46ca-beb9-145c5767ac88"},"_deposit":{"created_by":15,"id":"2000961","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000961"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000961","sets":["334:627:1728958044917"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-05-30","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では、CpGの腫瘍内投与が、CpGを投与した局所腫瘍に加え、CpG非投与部位の遠隔腫瘍に対しても抗腫瘍効果を示し、腫瘍微小環境中の腫瘍の浸潤や転移を促進するがん間質や腫瘍関連マクロファージ等の抗腫瘍免疫抑制に働く環境を改善し、がんの悪性化を抑えることを見出した。また、CpGはエクソソームの産生を促し、上記の作用はエクソソーム阻害剤により抑制され、CpGによる全身性の抗腫瘍効果やがん悪性化抑制作用にはエクソソームが関与している可能性を示した。さらにCpGとがん免疫療法を併用した治療法の探索では、CpGにがんワクチンやT細胞療法を併用すると抗腫瘍効果がさらに増強することを明らかにした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In this study, intratumoral administration of CpG showed anti-tumor effects not only on CpG-administered local tumors, but also on distant tumors at non-administered sites. We found that CpG improved the tumor microenvironment which promotes tumor invasion and metastasis, acts on anti-tumor immunosuppression, such as tumor stroma and tumor-associated macrophages, and suppressed malignant progression of tumors. In addition, CpG promoted the production of exosomes and above effects of CpG were inhibited by administration of exosome inhibitors. These results suggest exosomes were involved in systemic effects of CpG. Furthermore, the exploratory study of combination therapy of CpG and cancer immunotherapy showed the treatment of CpG with cancer vaccines and T cell therapy could exhibit more effective anti-tumor effects.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K16411","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"百瀬, 文康","creatorNameLang":"ja"},{"creatorName":"Momose, Fumiyasu","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-22"}],"filename":"2024RP0052.pdf","filesize":[{"value":"2 MB"}],"format":"application/pdf","url":{"label":"2024RP0052.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000961/files/2024RP0052.pdf"},"version_id":"888f2a3b-4274-4fb5-902f-d4895922a98c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CpG","subitem_subject_scheme":"Other"},{"subitem_subject":"がん悪性化制御","subitem_subject_scheme":"Other"},{"subitem_subject":"T細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"エクソソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"CpGによる活性化T細胞エクソソームを介したがん悪性化制御作用及び分子機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"CpGによる活性化T細胞エクソソームを介したがん悪性化制御作用及び分子機構の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of molecular mechanism of CpG-mediated suppression of malignant progression of tumors via activated T cell-released exosomes","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958044917"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-22"},"publish_date":"2024-10-22","publish_status":"0","recid":"2000961","relation_version_is_last":true,"title":["CpGによる活性化T細胞エクソソームを介したがん悪性化制御作用及び分子機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-22T05:04:32.120597+00:00"}