{"created":"2024-10-23T04:09:16.801148+00:00","id":2000972,"links":{},"metadata":{"_buckets":{"deposit":"177a9808-266a-4152-9362-3b2349318c07"},"_deposit":{"created_by":15,"id":"2000972","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000972"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000972","sets":["631:636:1728958087061"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-06-08","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"血管病変の異なるラットPAHモデルの肺におけるトランスクリプトームを比較解析し、標的遺伝子の同定を試みた。解析から、発現の異なる遺伝子(DEG)を選出し、さらに共通して変化するDEGにおいて共発現遺伝子の加重遺伝子ネットワーク解析を実施し、肺高血圧の新生内膜形成に関連する候補標的遺伝子を同定した。解析の結果、細胞接着分子A、炎症関連分子Bを同定した。炎症関連分子B欠損ラットを作成し、その表現型解析を行った。分子Bノックアウトラットでは、モノクロタリン誘発ラットの生存率が低下し、高度の肺血管病変を認めた。分子Bは血管平滑筋の増殖、分化状態維持に重要であることが示された。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In this study, we attempted to identify target genes by comparative analysis of transcriptomes in the lungs of rat PAH models with different vascular lesions. From the analysis, differentially expressed genes (DEGs) were selected, and a weighted gene network analysis of co-expressed genes in commonly altered DEGs was performed to identify candidate target genes related to neointima formation in pulmonary hypertension. As a result, cell adhesion molecule A and inflammation-related molecule B were identified. Inflammation-related molecule B-deficient rats were generated and phenotypically analyzed. Molecule B knockout rats showed reduced survival and severe pulmonary vascular lesions in monocrotaline-induced rats. Molecule B was shown to be important in maintaining the proliferative and differentiation state of vascular smooth muscle.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(基盤研究(C))研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K08565","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"淀谷, 典子","creatorNameLang":"ja"},{"creatorName":"Yodoya, Noriko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"丸山, 一男","creatorNameLang":"ja"},{"creatorName":"Maruyama, Kazuo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"西村, 有平","creatorNameLang":"ja"},{"creatorName":"Nishimura, Yuhei","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"澤田, 博文","creatorNameLang":"ja"},{"creatorName":"Sawada, Hirofumi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"三谷, 義英","creatorNameLang":"ja"},{"creatorName":"Mitani, Yoshihide","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-23"}],"filename":"2024RP0062.pdf","filesize":[{"value":"163 KB"}],"format":"application/pdf","url":{"label":"2024RP0062.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000972/files/2024RP0062.pdf"},"version_id":"61ac6ef6-a263-4c3a-b429-0a8c3f79121e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肺高血圧","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスクリプトーム","subitem_subject_scheme":"Other"},{"subitem_subject":"創薬","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肺高血圧症の肺動脈新生内膜形成の機序：肺トランスクリプトーム解析によるアプローチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肺高血圧症の肺動脈新生内膜形成の機序：肺トランスクリプトーム解析によるアプローチ","subitem_title_language":"ja"},{"subitem_title":"Mechanisms of neointima formation in pulmonary hypertension: an approach using pulmonary transcriptome analysis.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958087061"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-23"},"publish_date":"2024-10-23","publish_status":"0","recid":"2000972","relation_version_is_last":true,"title":["肺高血圧症の肺動脈新生内膜形成の機序：肺トランスクリプトーム解析によるアプローチ"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-23T04:25:52.171843+00:00"}