{"created":"2024-10-23T06:03:31.262417+00:00","id":2000977,"links":{},"metadata":{"_buckets":{"deposit":"21a01095-3690-41ff-935d-d8308c3c4520"},"_deposit":{"created_by":15,"id":"2000977","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000977"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000977","sets":["631:636:1728958087061"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-06-26","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"難治性白血病治療の最後の砦である造血細胞移植において、移植片対宿主病（Graft-Versus Host disease; GVHD）は移植後免疫作用による重篤な合併症です。今回、ドナーマウス由来の細胞から誘導し作成した抑制性マクロファージを、患者に見立てたGVHDを発症するレシピエントマウスに投与することによって、GVHDの重症化を軽減することに成功しました。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Graft-Versus Host disease (GVHD) is a serious complication of post-transplant immune effects in hematopoietic cell transplantation, the last resort in the treatment of refractory leukemia. In this study, we succeeded in reducing the severity of GVHD by inducing suppressive macrophages from cells derived from donor mice and injecting them into recipient mice that develop GVHD as if they were patients.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K17376","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"花木, 良","creatorNameLang":"ja"},{"creatorName":"Hanaki, Ryo","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-23"}],"filename":"2024RP0067.pdf","filesize":[{"value":"695 KB"}],"format":"application/pdf","url":{"label":"2024RP0067.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000977/files/2024RP0067.pdf"},"version_id":"3f7aee6b-881f-4341-a827-ae1b3204187b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"GVHD","subitem_subject_scheme":"Other"},{"subitem_subject":"造血細胞移植","subitem_subject_scheme":"Other"},{"subitem_subject":"M2 macrophage","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ドナー骨髄由来M2マクロファージによる急性GVHDの新規治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ドナー骨髄由来M2マクロファージによる急性GVHDの新規治療","subitem_title_language":"ja"},{"subitem_title":"Novel treatment of acute GVHD with donor bone marrow-derived M2 macrophages","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958087061"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-23"},"publish_date":"2024-10-23","publish_status":"0","recid":"2000977","relation_version_is_last":true,"title":["ドナー骨髄由来M2マクロファージによる急性GVHDの新規治療"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-23T06:09:56.025824+00:00"}