{"created":"2024-10-24T00:02:26.023297+00:00","id":2000979,"links":{},"metadata":{"_buckets":{"deposit":"f1aa5a94-b4e4-4470-9df1-df875b44f95d"},"_deposit":{"created_by":15,"id":"2000979","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000979"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000979","sets":["631:636:1728958087061"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-04-21","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"最近、非痙攣性発作がくも膜下出血(SAH)の予後不良因子として知られるようになってきた。基礎研究では早期脳損傷と呼ばれるSAH特有の脳障害が予後不良因子として重要視されている。我々は最近、マトリセルラー蛋白の１つであるテネイシンC (TNC)がSAH後の脳において高発現し、神経細胞アポトーシスの原因になることを報告した。神経細胞アポトーシスはSAH後の早期脳損傷においても、てんかん原性獲得過程においても重要と考えられている。そこで本研究では、SAHモデルマウスを用いて、神経細胞アポトーシス、TNCと非痙攣性発作の間の関係を明らかにした。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Recently, nonconvulsive seizures have become known as a poor prognostic factor for subarachnoid hemorrhage (SAH) after cerebral aneurysmal rupture. In basic research, brain damage peculiar to SAH, called early brain injury, is considered important as a poor prognostic factor. We recently reported that one of the matricellular proteins, tenascin-C (TNC), was highly expressed in the brain after SAH and caused neuronal apoptosis. Neuronal apoptosis is thought to be important both in early brain injury after SAH and in the acquisition of epileptogenicity. In this study, thus we clarified the relationships among neuronal apoptosis, TNC upregulation, and non-convulsive seizures using SAH model mice.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2020年度～2022年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"20K17963","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川北, 文博","creatorNameLang":"ja"},{"creatorName":"Kawakita, Fumihiro","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-24"}],"filename":"2024RP0069.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","url":{"label":"2024RP0069.pdf","url":"https://mie-u.repo.nii.ac.jp/record/2000979/files/2024RP0069.pdf"},"version_id":"3c3caf66-9d52-494b-bc75-ed2fa8a90a66"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"くも膜下出血","subitem_subject_scheme":"Other"},{"subitem_subject":"てんかん","subitem_subject_scheme":"Other"},{"subitem_subject":"早期脳損傷","subitem_subject_scheme":"Other"},{"subitem_subject":"神経細胞アポトーシス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"てんかんに着目したくも膜下出血後早期脳損傷の病態解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"てんかんに着目したくも膜下出血後早期脳損傷の病態解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the pathology of early brain injury after subarachnoid hemorrhage focusing on epilepsy","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958087061"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-24"},"publish_date":"2024-10-24","publish_status":"0","recid":"2000979","relation_version_is_last":true,"title":["てんかんに着目したくも膜下出血後早期脳損傷の病態解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-24T00:08:54.437732+00:00"}