{"created":"2024-10-24T00:21:29.465133+00:00","id":2000980,"links":{},"metadata":{"_buckets":{"deposit":"2c81c4d9-87da-4786-acec-1d56fff060e7"},"_deposit":{"created_by":15,"id":"2000980","owner":"15","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"2000980"},"status":"published"},"_oai":{"id":"oai:mie-u.repo.nii.ac.jp:02000980","sets":["631:636:1728958087061"]},"author_link":[],"item_8_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2023-06-14","bibliographicIssueDateType":"Issued"}}]},"item_8_description_14":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_description_4":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"近年、炎症の収束にリンパ管が重要な働きをする事が明らかになってきた。炎症時にリンパ管新生を促進する因子についてはVEGF-Cを含め多数報告されてきたが、リンパ管新生を抑制する因子については分かっていなかった。\n申請者らは炎症時にリンパ管新生を阻害する因子を探索し、細胞外マトリクスの1つであるTenascin-Cが炎症早期のリンパ管新生を抑制することを発見した。Tenascin-Cはインテグリンを介したp38 MAPKのリン酸化を誘導し、リンパ管内皮細胞の増殖の抑制、アポトーシスの誘導に関わることがわかった。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"In recent years, it has become clear that lymphatic vessels play an important role in the resolution of inflammation. Lymphangiogenic factors, including VEGF-C, have been reported, but little is known about the factors that inhibit lymphangiogenesis during inflammation. The applicant searched for a negative regulator of lymphangiogenesis during inflammation, and found that Tenascin-C, an extracellular matrix protein, inhibits lymphangiogenesis in the early stage of inflammation. Tenascin-C bound to integrin αvβ1 and induced phosphorylation of p38 MAPK, thereby suppressing proliferation and promoting apoptosis of lymphatic endothelial cells.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_8_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"2021年度～2022年度科学研究費補助金(若手研究)研究成果報告書","subitem_description_type":"Other"}]},"item_8_description_64":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_description":"21K15417","subitem_description_type":"Other"}]},"item_8_publisher_30":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"三重大学"}]},"item_8_text_31":{"attribute_name":"出版者（ヨミ）","attribute_value_mlt":[{"subitem_text_value":"ミエダイガク"}]},"item_8_text_65":{"attribute_name":"item_8_text_65","attribute_value_mlt":[{"subitem_text_value":"Kaken / 科研費報告書"}]},"item_8_version_type_15":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加藤, 大祐","creatorNameLang":"ja"},{"creatorName":"Kato, Daisuke","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-10-24"}],"filename":"2024RP0070.pdf","filesize":[{"value":"73 KB"}],"format":"application/pdf","url":{"url":"https://mie-u.repo.nii.ac.jp/record/2000980/files/2024RP0070.pdf"},"version_id":"a4c8a450-8a87-449a-bc15-fcc80b94aca5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Tenascin-C","subitem_subject_scheme":"Other"},{"subitem_subject":"リンパ管","subitem_subject_scheme":"Other"},{"subitem_subject":"negative regulator","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"インテグリン","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"リンパ管新生阻害因子による炎症調節機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リンパ管新生阻害因子による炎症調節機構の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of negative regulator for lymphangiogenesis during inflammation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"15","path":["1728958087061"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-10-24"},"publish_date":"2024-10-24","publish_status":"0","recid":"2000980","relation_version_is_last":true,"title":["リンパ管新生阻害因子による炎症調節機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2024-10-24T00:28:33.908885+00:00"}